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• W2115753419 endingPage "588" @default.
• W2115753419 startingPage "579" @default.
• W2115753419 abstract "A-type K(+) currents are key determinants of repetitive activity and synaptic integration. Although several gene families have been shown to code for A-type channel subunits, recent studies have suggested that Kv4 family channels are the principal contributors to A-type channels in the somatodendritic membrane of mammalian brain neurons. If this hypothesis is correct, there should be a strong correlation between Kv4 family mRNA and A-type channel protein or aggregate channel currents. To test this hypothesis, quantitative single-cell reverse transcription-PCR analysis of Kv4 family mRNA was combined with voltage-clamp analysis of A-type K(+) currents in acutely isolated neurons. These studies revealed that Kv4.2 mRNA abundance was linearly related to A-type K(+) current amplitude in neostriatal medium spiny neurons and cholinergic interneurons, in globus pallidus neurons, and in basal forebrain cholinergic neurons. In contrast, there was not a significant correlation between estimates of Kv4.1 or Kv4.3 mRNA abundance and A-type K(+) current amplitudes. These results argue that Kv4.2 subunits are major constituents of somatodendritic A-type K(+) channels in these four types of neuron. In spite of this common structural feature, there were significant differences in the voltage dependence and kinetics of A-type currents in the cell types studied, suggesting that other determinants may create important functional differences between A-type K(+) currents." @default.
• W2115753419 created "2016-06-24" @default.
• W2115753419 creator A5005081394 @default.
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• W2115753419 date "2000-01-15" @default.
• W2115753419 modified "2023-10-03" @default.
• W2115753419 title "Kv4.2 mRNA Abundance and A-Type K⁺Current Amplitude Are Linearly Related in Basal Ganglia and Basal Forebrain Neurons" @default.
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• W2115753419 doi "https://doi.org/10.1523/jneurosci.20-02-00579.2000" @default.
• W2115753419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772407" @default.
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