FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115859911> ?p ?o ?g. }

• W2115859911 endingPage "739" @default.
• W2115859911 startingPage "733" @default.
• W2115859911 abstract "Background The aim of the present study was to treat unstable asthma according to exhaled nitric oxide (eNO) and induced-sputum eosinophils (sEos) levels to assess if this strategy is better than the conventional approach based on symptoms and function to achieve asthma control. Methods Fourteen patients with mild-to-moderate persistent asthma (6 men, 8 women) were recruited. During the recruitment visit, the patients, previously treated for asthma following Global Initiative for Asthma recommendations, underwent clinical evaluation and pulmonary function tests (PFTs). Then, after 4 weeks of washout from inhaled antiinflammatory treatment, the patients underwent a basal visit performing PFTs, challenge test to methacholine, and determination of eNO and sEos counts. These procedures were repeated after 3, 6, and 12 months while the patients were treated with inhaled steroids in a stepwise fashion according to eNO and sEos values. Results At the end of the study, a significant decrease in eNO and sEos was observed (57.2 ± 32.8 parts per billion [ppb] vs 22.1 ± 10.8 ppb, p < 0.01; and 27.1 ± 27.1% vs 3.7 ± 3.5%, p < 0.01, respectively). A close correlation (r2 = 0.41, p < 0.01) between the percentage change of eNO and sEos was observed only after 6 months. Patients treated according to the levels of these inflammatory markers had fewer symptoms and fewer exacerbations compared to those the year before when they were conventionally treated. Conclusions Our results show the usefulness of eNO and sEos for titrating treatment in asthmatic patients in order to achieve better long-term control of the disease. The eNO decrease reflects adequately the reduction of sEos only after 6 months. The aim of the present study was to treat unstable asthma according to exhaled nitric oxide (eNO) and induced-sputum eosinophils (sEos) levels to assess if this strategy is better than the conventional approach based on symptoms and function to achieve asthma control. Fourteen patients with mild-to-moderate persistent asthma (6 men, 8 women) were recruited. During the recruitment visit, the patients, previously treated for asthma following Global Initiative for Asthma recommendations, underwent clinical evaluation and pulmonary function tests (PFTs). Then, after 4 weeks of washout from inhaled antiinflammatory treatment, the patients underwent a basal visit performing PFTs, challenge test to methacholine, and determination of eNO and sEos counts. These procedures were repeated after 3, 6, and 12 months while the patients were treated with inhaled steroids in a stepwise fashion according to eNO and sEos values. At the end of the study, a significant decrease in eNO and sEos was observed (57.2 ± 32.8 parts per billion [ppb] vs 22.1 ± 10.8 ppb, p < 0.01; and 27.1 ± 27.1% vs 3.7 ± 3.5%, p < 0.01, respectively). A close correlation (r2 = 0.41, p < 0.01) between the percentage change of eNO and sEos was observed only after 6 months. Patients treated according to the levels of these inflammatory markers had fewer symptoms and fewer exacerbations compared to those the year before when they were conventionally treated. Our results show the usefulness of eNO and sEos for titrating treatment in asthmatic patients in order to achieve better long-term control of the disease. The eNO decrease reflects adequately the reduction of sEos only after 6 months." @default.
• W2115859911 created "2016-06-24" @default.
• W2115859911 creator A5011441252 @default.
• W2115859911 creator A5025040294 @default.
• W2115859911 creator A5026932721 @default.
• W2115859911 creator A5060178661 @default.
• W2115859911 date "2008-10-01" @default.
• W2115859911 modified "2023-09-23" @default.
• W2115859911 title "Usefulness of Exhaled Nitric Oxide and Sputum Eosinophils in the Long-term Control of Eosinophilic Asthma" @default.
• W2115859911 cites W1553126713 @default.
• W2115859911 cites W1953300272 @default.
• W2115859911 cites W1966718625 @default.
• W2115859911 cites W1974698157 @default.
• W2115859911 cites W1988685962 @default.
• W2115859911 cites W1992105306 @default.
• W2115859911 cites W2043365196 @default.
• W2115859911 cites W2097410604 @default.
• W2115859911 cites W2098997466 @default.
• W2115859911 cites W2105769151 @default.
• W2115859911 cites W2109781176 @default.
• W2115859911 cites W2123002410 @default.
• W2115859911 cites W2126010076 @default.
• W2115859911 cites W2127303736 @default.
• W2115859911 cites W2133761759 @default.
• W2115859911 cites W2134106931 @default.
• W2115859911 cites W2150413482 @default.
• W2115859911 cites W2152345375 @default.
• W2115859911 cites W2154263136 @default.
• W2115859911 cites W2155589243 @default.
• W2115859911 cites W2161024802 @default.
• W2115859911 cites W2165175201 @default.
• W2115859911 cites W2170413821 @default.
• W2115859911 cites W4211006694 @default.
• W2115859911 doi "https://doi.org/10.1378/chest.08-0763" @default.
• W2115859911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18842911" @default.
• W2115859911 hasPublicationYear "2008" @default.
• W2115859911 type Work @default.
• W2115859911 sameAs 2115859911 @default.
• W2115859911 citedByCount "54" @default.
• W2115859911 countsByYear W21158599112012 @default.
• W2115859911 countsByYear W21158599112013 @default.
• W2115859911 countsByYear W21158599112014 @default.
• W2115859911 countsByYear W21158599112016 @default.
• W2115859911 countsByYear W21158599112017 @default.
• W2115859911 countsByYear W21158599112021 @default.
• W2115859911 countsByYear W21158599112022 @default.
• W2115859911 countsByYear W21158599112023 @default.
• W2115859911 crossrefType "journal-article" @default.
• W2115859911 hasAuthorship W2115859911A5011441252 @default.
• W2115859911 hasAuthorship W2115859911A5025040294 @default.
• W2115859911 hasAuthorship W2115859911A5026932721 @default.
• W2115859911 hasAuthorship W2115859911A5060178661 @default.
• W2115859911 hasConcept C126322002 @default.
• W2115859911 hasConcept C142724271 @default.
• W2115859911 hasConcept C2776042228 @default.
• W2115859911 hasConcept C2776178081 @default.
• W2115859911 hasConcept C2776301714 @default.
• W2115859911 hasConcept C2777714996 @default.
• W2115859911 hasConcept C2780333948 @default.
• W2115859911 hasConcept C2781069245 @default.
• W2115859911 hasConcept C2781142857 @default.
• W2115859911 hasConcept C2781260171 @default.
• W2115859911 hasConcept C71924100 @default.
• W2115859911 hasConcept C75603125 @default.
• W2115859911 hasConcept C90924648 @default.
• W2115859911 hasConceptScore W2115859911C126322002 @default.
• W2115859911 hasConceptScore W2115859911C142724271 @default.
• W2115859911 hasConceptScore W2115859911C2776042228 @default.
• W2115859911 hasConceptScore W2115859911C2776178081 @default.
• W2115859911 hasConceptScore W2115859911C2776301714 @default.
• W2115859911 hasConceptScore W2115859911C2777714996 @default.
• W2115859911 hasConceptScore W2115859911C2780333948 @default.
• W2115859911 hasConceptScore W2115859911C2781069245 @default.
• W2115859911 hasConceptScore W2115859911C2781142857 @default.
• W2115859911 hasConceptScore W2115859911C2781260171 @default.
• W2115859911 hasConceptScore W2115859911C71924100 @default.
• W2115859911 hasConceptScore W2115859911C75603125 @default.
• W2115859911 hasConceptScore W2115859911C90924648 @default.
• W2115859911 hasIssue "4" @default.
• W2115859911 hasLocation W21158599111 @default.
• W2115859911 hasOpenAccess W2115859911 @default.
• W2115859911 hasPrimaryLocation W21158599111 @default.
• W2115859911 hasRelatedWork W1135014894 @default.
• W2115859911 hasRelatedWork W2037191307 @default.
• W2115859911 hasRelatedWork W2073354755 @default.
• W2115859911 hasRelatedWork W2099861526 @default.
• W2115859911 hasRelatedWork W2201511672 @default.
• W2115859911 hasRelatedWork W2336039432 @default.
• W2115859911 hasRelatedWork W2419083282 @default.
• W2115859911 hasRelatedWork W3005465724 @default.
• W2115859911 hasRelatedWork W3114108531 @default.
• W2115859911 hasRelatedWork W2123572622 @default.
• W2115859911 hasVolume "134" @default.
• W2115859911 isParatext "false" @default.
• W2115859911 isRetracted "false" @default.
• W2115859911 magId "2115859911" @default.
• W2115859911 workType "article" @default.