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- W2116877158 abstract "Ha evidencias de que o estrogeno altera aspectos estruturais e funcionais do cerebro. O efeitopositivo da terapia de reposicao estrogenica (TRE), em mulheres pos-menopausadas, e umassunto controverso.O presente estudo tem o objetivo de avaliar o efeito da TRE sobre as funcoes cognitivas. Mulheres,histerectomizadas e saudaveis, participaram de um estudo randomizado e duplo-cego, recebendo aTRE com 0,625 mg diario de estrogenio equino conjugado (n= 27) ou placebo (n= 32) e foramtestadas quanto ao desempenho em testes cognitivos validos e confiaveis antes e depois de 6 ciclos de28 dias de tratamento. Em varios testes cognitivos, o estrogeno reduziu os escores deles de formaestatisticamente semelhante ao placebo (p>0,05). Concluimos que a reposicao estrogenica em pacientes na pos-menopausa com as caracteristicas de nossaamostra nao promove melhora da cognicao de forma significativamentediferente de placebo. Estudos futuros saonecessarios para a confirmacao dos presentes resultadosencontrados.SUMMARYThere are evidences that estrogen influences aspects of brainfunction and structure.A positive effect of estrogen replacement therapy (ERT) oncognition in postmenopausal women is a controversial issue.The aim of this study is to evaluate the effect of ERTon cognition.Hysterectomized, assymtomatic and healthy women tookpart of this randomized double-blind study. They receivedequine conjugated estrogen 0.625 mg per day (n= 27) orplacebo (n= 32), and were tested in a valid and reliableneuropsychological test battery before and after six 28day cycles treatment. No beneficial effect of ERT was foundon cognitive abilities of healthy postmenopausal womenand compared to placebo group. During these measurementsboth groups showed significant reduction (p<0,05)in the global cognitive tests scores. We concluded that estrogenreplacement therapy does not improve mood andanxiety significantly more than placebo in postmenopausalwomen considering the caracteristics of our sample. Furtherstudies are necessary to confirm these found results." @default.
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- W2116877158 date "2006-01-01" @default.
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- W2116877158 title "Efeito da terapia de reposição estrogênica sobre a cognição em mulheres pós-menopausas histerectomizadas" @default.
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