FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119465020> ?p ?o ?g. }

• W2119465020 endingPage "1202" @default.
• W2119465020 startingPage "1197" @default.
• W2119465020 abstract "Lysosphingolipids, which lack the fatty acid moiety of sphingolipids, are known to be accumulated in some variants of sphingolipid storage diseases. Here, we report that lysosphingolipids with naturally occurring stereochemical configurations induce apoptosis in mouse neuroblastoma Neuro2a cells. The intracellular dehydrogenase activity and [3H]thymidine incorporation of Neuro2a cells were strongly suppressed by the addition of lysosphingolipids in a dose-dependent manner, whereas the parental sphingolipids had no effect. Intra-nucleosomal DNA fragmentation, chromatin condensation, and phosphatidylserine externalization, which are typical features of apoptosis, were observed when the cells were cultured with 40–80 μM of lysosphingolipids for 24–48 h in the presence of 5% fetal calf serum. Activation of caspase-3-like enzyme occurred after addition of lysosphingolipids followed by incubation at 37 °C for 24 h. The addition of an inhibitor of caspases, ZVAD-fmk, to the Neuro2a cell culture completely inhibited the elevation of caspase-3 activity but not the DNA fragmentation. These results may indicate that a caspase-3 independent signaling pathway is involved in the lysosphingolipid-induced apoptosis and suggest that accumulation of lysosphingolipids, but not parental sphingolipids, triggers the apoptotic cascade in neuronal cells of patients with sphingolipidoses. —Sueyoshi, N., T. Maehara, and M. Ito. Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations." @default.
• W2119465020 created "2016-06-24" @default.
• W2119465020 creator A5010608385 @default.
• W2119465020 creator A5015065431 @default.
• W2119465020 creator A5085012945 @default.
• W2119465020 date "2001-08-01" @default.
• W2119465020 modified "2023-09-23" @default.
• W2119465020 title "Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations" @default.
• W2119465020 cites W1556905989 @default.
• W2119465020 cites W1601701914 @default.
• W2119465020 cites W1914590050 @default.
• W2119465020 cites W1972866355 @default.
• W2119465020 cites W1977217230 @default.
• W2119465020 cites W1993296615 @default.
• W2119465020 cites W2009373735 @default.
• W2119465020 cites W2017191638 @default.
• W2119465020 cites W2047867213 @default.
• W2119465020 cites W2052860581 @default.
• W2119465020 cites W2059033002 @default.
• W2119465020 cites W2066091091 @default.
• W2119465020 cites W2079930884 @default.
• W2119465020 cites W2088696301 @default.
• W2119465020 cites W2096139474 @default.
• W2119465020 cites W2098500508 @default.
• W2119465020 cites W2099717197 @default.
• W2119465020 cites W2131292102 @default.
• W2119465020 cites W2142301272 @default.
• W2119465020 cites W2151260274 @default.
• W2119465020 cites W2151378459 @default.
• W2119465020 cites W2156179144 @default.
• W2119465020 cites W2218717935 @default.
• W2119465020 cites W38360628 @default.
• W2119465020 cites W38937041 @default.
• W2119465020 cites W4235428970 @default.
• W2119465020 doi "https://doi.org/10.1016/s0022-2275(20)31569-8" @default.
• W2119465020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11483620" @default.
• W2119465020 hasPublicationYear "2001" @default.
• W2119465020 type Work @default.
• W2119465020 sameAs 2119465020 @default.
• W2119465020 citedByCount "24" @default.
• W2119465020 countsByYear W21194650202015 @default.
• W2119465020 countsByYear W21194650202016 @default.
• W2119465020 countsByYear W21194650202021 @default.
• W2119465020 countsByYear W21194650202022 @default.
• W2119465020 crossrefType "journal-article" @default.
• W2119465020 hasAuthorship W2119465020A5010608385 @default.
• W2119465020 hasAuthorship W2119465020A5015065431 @default.
• W2119465020 hasAuthorship W2119465020A5085012945 @default.
• W2119465020 hasBestOaLocation W21194650201 @default.
• W2119465020 hasConcept C153911025 @default.
• W2119465020 hasConcept C155878803 @default.
• W2119465020 hasConcept C170493617 @default.
• W2119465020 hasConcept C185592680 @default.
• W2119465020 hasConcept C18903297 @default.
• W2119465020 hasConcept C190283241 @default.
• W2119465020 hasConcept C191015642 @default.
• W2119465020 hasConcept C2777851122 @default.
• W2119465020 hasConcept C2778703144 @default.
• W2119465020 hasConcept C2778918659 @default.
• W2119465020 hasConcept C2779637612 @default.
• W2119465020 hasConcept C31573885 @default.
• W2119465020 hasConcept C41625074 @default.
• W2119465020 hasConcept C43759708 @default.
• W2119465020 hasConcept C54355233 @default.
• W2119465020 hasConcept C55493867 @default.
• W2119465020 hasConcept C61705674 @default.
• W2119465020 hasConcept C79879829 @default.
• W2119465020 hasConcept C81885089 @default.
• W2119465020 hasConcept C86803240 @default.
• W2119465020 hasConcept C95444343 @default.
• W2119465020 hasConcept C98424977 @default.
• W2119465020 hasConceptScore W2119465020C153911025 @default.
• W2119465020 hasConceptScore W2119465020C155878803 @default.
• W2119465020 hasConceptScore W2119465020C170493617 @default.
• W2119465020 hasConceptScore W2119465020C185592680 @default.
• W2119465020 hasConceptScore W2119465020C18903297 @default.
• W2119465020 hasConceptScore W2119465020C190283241 @default.
• W2119465020 hasConceptScore W2119465020C191015642 @default.
• W2119465020 hasConceptScore W2119465020C2777851122 @default.
• W2119465020 hasConceptScore W2119465020C2778703144 @default.
• W2119465020 hasConceptScore W2119465020C2778918659 @default.
• W2119465020 hasConceptScore W2119465020C2779637612 @default.
• W2119465020 hasConceptScore W2119465020C31573885 @default.
• W2119465020 hasConceptScore W2119465020C41625074 @default.
• W2119465020 hasConceptScore W2119465020C43759708 @default.
• W2119465020 hasConceptScore W2119465020C54355233 @default.
• W2119465020 hasConceptScore W2119465020C55493867 @default.
• W2119465020 hasConceptScore W2119465020C61705674 @default.
• W2119465020 hasConceptScore W2119465020C79879829 @default.
• W2119465020 hasConceptScore W2119465020C81885089 @default.
• W2119465020 hasConceptScore W2119465020C86803240 @default.
• W2119465020 hasConceptScore W2119465020C95444343 @default.
• W2119465020 hasConceptScore W2119465020C98424977 @default.
• W2119465020 hasIssue "8" @default.
• W2119465020 hasLocation W21194650201 @default.
• W2119465020 hasOpenAccess W2119465020 @default.
• W2119465020 hasPrimaryLocation W21194650201 @default.
• W2119465020 hasRelatedWork W124089116 @default.

• next