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- W2120110189 abstract "Secretin stimulation clears the cytoplasm of intralobular pancreatic duct cells in pigs of tubulovesicles and causes these cells to secrete HCO3- into the pancreatic juice. To determine whether the clearance of cytoplasmic tubulovesicles involves the microtubule system and is important for initiation of HCO3- secretion, the effect of the microtubule poison colchicine on duct cell morphology and pancreatic HCO3- secretion was measured in anaesthetized pigs. Before colchicine, secretin reduced the density of tubulovesicles in the cytoplasm of pancreatic duct cells from 92 ± 8 U to 8 ± 2 U and initiated pancreatic secretion of 176 ± 21 μmol min-1 HCO3-. After colchicine, secretin failed to lower duct cell tubulovesicle density and caused the secretion of only 77 ± 14μmol min-1 HCO3-. By contrast, lumicolchicine, an isomer of colchicine that does not affect microtubules, did not inhibit pancreatic HCO3 secretion. Colchicine did not reduce carbonic anhydrase or Na,K-ATPase activities in in-vitro assays. The clearance of tubulovesicles from the cytoplasm of pancreatic duct cells therefore seems to be microtubule-dependent and important for the pancreatic HCO3- secretion." @default.
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- W2120110189 date "1990-04-01" @default.
- W2120110189 modified "2023-09-26" @default.
- W2120110189 title "Colchicine inhibits the effects of secretin on pancreatic duct cell tubulovesicles and HC03secretion in the pig" @default.
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- W2120110189 doi "https://doi.org/10.1111/j.1748-1716.1990.tb08876.x" @default.
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