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- W2122302330 abstract "The “trace” amines 2-phenylethylamine (Ia; PEA) and tryptamine (IIa; T) are endogenous CNS stimulants with rapid turnover rates. It has been suggested (Dewhurst, 1968; Sabelli and Mosnaim, 1974) that in depression there is a functional deficiency of one or both of these amines in the brain. Brain levels of PEA and T can be greatly increased in laboratory animals by the administration of monoamine oxidase (MAO)-inhibiting antidepressants (e.g. phenelzine, tranylcypromine) (Philips and Boulton, 1979) but this treatment is not selective and increases brain levels of other endogenous amines. To study the role of PEA and T in affective disorders, it is necessary to increase brain levels of individual endogenous amines and observe the biochemical and behavioural changes that result. Since MAO inhibitors which selectively inhibit the metabolism of individual brain amines do not exist, alternative methods of increasing brain levels of amines must be utilized. In our laboratory, we have investigated the usefulness of prodrugs with the hope that they may alter advantageously the pharmacokinetics of the amine released by the prodrug, such that brain levels of amine are increased, prolonged or better controlled." @default.
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- W2122302330 date "1985-01-01" @default.
- W2122302330 modified "2023-09-26" @default.
- W2122302330 title "Prodrugs of Trace Amines" @default.
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- W2122302330 doi "https://doi.org/10.1007/978-1-4612-5010-4_15" @default.
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