FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127176239> ?p ?o ?g. }

• W2127176239 endingPage "622" @default.
• W2127176239 startingPage "609" @default.
• W2127176239 abstract "Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mouse models exhibiting striatal degeneration, have demonstrated changes in the expression of many important genes with a large proportion of changes being observed in the striatal-enriched genes. These investigations have raised questions about how enrichment of particular transcripts in the striatum can lead to its selective vulnerability to neurodegeneration. Monitoring the expression changes of striatal-enriched genes during the course of the disease may be informative about their potential involvement in selective degeneration. In this study, we analyzed a Serial Analysis of Gene Expression (SAGE) database (www.mouseatlas.org) and compared the mouse striatum to 18 other brain regions to generate a novel list of striatal-enriched transcripts. These novel striatal-enriched transcripts were subsequently evaluated for expression changes in the YAC128 mouse model of HD, and differentially expressed transcripts were further examined in human post-mortem caudate samples. We identified transcripts with altered expression in YAC128 mice, which also showed consistent expression changes in human post-mortem tissue. The identification of novel striatal-enriched genes with altered expression in HD offers new avenues of study, leading towards a better understanding of specific pathways involved in the selective degeneration of striatal neurons in HD." @default.
• W2127176239 created "2016-06-24" @default.
• W2127176239 creator A5018893803 @default.
• W2127176239 creator A5028295418 @default.
• W2127176239 creator A5062884561 @default.
• W2127176239 creator A5065488747 @default.
• W2127176239 creator A5071837576 @default.
• W2127176239 creator A5079216658 @default.
• W2127176239 date "2009-11-23" @default.
• W2127176239 modified "2023-10-16" @default.
• W2127176239 title "Expression analysis of novel striatal-enriched genes in Huntington disease" @default.
• W2127176239 cites W1515840075 @default.
• W2127176239 cites W1577577364 @default.
• W2127176239 cites W1974790023 @default.
• W2127176239 cites W1985517826 @default.
• W2127176239 cites W1993191686 @default.
• W2127176239 cites W1998815929 @default.
• W2127176239 cites W1999981386 @default.
• W2127176239 cites W2001306976 @default.
• W2127176239 cites W2015789019 @default.
• W2127176239 cites W2016732271 @default.
• W2127176239 cites W2017182831 @default.
• W2127176239 cites W2019634326 @default.
• W2127176239 cites W2032864658 @default.
• W2127176239 cites W2038303935 @default.
• W2127176239 cites W2051065375 @default.
• W2127176239 cites W2051353156 @default.
• W2127176239 cites W2051432574 @default.
• W2127176239 cites W2059801721 @default.
• W2127176239 cites W2086996808 @default.
• W2127176239 cites W2089338632 @default.
• W2127176239 cites W2095907724 @default.
• W2127176239 cites W2096737446 @default.
• W2127176239 cites W2108477230 @default.
• W2127176239 cites W2112516420 @default.
• W2127176239 cites W2115999215 @default.
• W2127176239 cites W2119833067 @default.
• W2127176239 cites W2120218847 @default.
• W2127176239 cites W2121926054 @default.
• W2127176239 cites W2122440289 @default.
• W2127176239 cites W2128867995 @default.
• W2127176239 cites W2130668838 @default.
• W2127176239 cites W2135732941 @default.
• W2127176239 cites W2136541816 @default.
• W2127176239 cites W2140881278 @default.
• W2127176239 cites W2156550735 @default.
• W2127176239 cites W2160748841 @default.
• W2127176239 cites W2168583567 @default.
• W2127176239 cites W2170256902 @default.
• W2127176239 doi "https://doi.org/10.1093/hmg/ddp527" @default.
• W2127176239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2807369" @default.
• W2127176239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19934114" @default.
• W2127176239 hasPublicationYear "2009" @default.
• W2127176239 type Work @default.
• W2127176239 sameAs 2127176239 @default.
• W2127176239 citedByCount "44" @default.
• W2127176239 countsByYear W21271762392012 @default.
• W2127176239 countsByYear W21271762392013 @default.
• W2127176239 countsByYear W21271762392014 @default.
• W2127176239 countsByYear W21271762392015 @default.
• W2127176239 countsByYear W21271762392016 @default.
• W2127176239 countsByYear W21271762392017 @default.
• W2127176239 countsByYear W21271762392019 @default.
• W2127176239 countsByYear W21271762392020 @default.
• W2127176239 countsByYear W21271762392021 @default.
• W2127176239 countsByYear W21271762392022 @default.
• W2127176239 countsByYear W21271762392023 @default.
• W2127176239 crossrefType "journal-article" @default.
• W2127176239 hasAuthorship W2127176239A5018893803 @default.
• W2127176239 hasAuthorship W2127176239A5028295418 @default.
• W2127176239 hasAuthorship W2127176239A5062884561 @default.
• W2127176239 hasAuthorship W2127176239A5065488747 @default.
• W2127176239 hasAuthorship W2127176239A5071837576 @default.
• W2127176239 hasAuthorship W2127176239A5079216658 @default.
• W2127176239 hasBestOaLocation W21271762392 @default.
• W2127176239 hasConcept C104317684 @default.
• W2127176239 hasConcept C142724271 @default.
• W2127176239 hasConcept C150194340 @default.
• W2127176239 hasConcept C169760540 @default.
• W2127176239 hasConcept C2776925932 @default.
• W2127176239 hasConcept C2777670902 @default.
• W2127176239 hasConcept C2779134260 @default.
• W2127176239 hasConcept C2780062018 @default.
• W2127176239 hasConcept C2780647506 @default.
• W2127176239 hasConcept C513476851 @default.
• W2127176239 hasConcept C54355233 @default.
• W2127176239 hasConcept C71924100 @default.
• W2127176239 hasConcept C86803240 @default.
• W2127176239 hasConceptScore W2127176239C104317684 @default.
• W2127176239 hasConceptScore W2127176239C142724271 @default.
• W2127176239 hasConceptScore W2127176239C150194340 @default.
• W2127176239 hasConceptScore W2127176239C169760540 @default.
• W2127176239 hasConceptScore W2127176239C2776925932 @default.
• W2127176239 hasConceptScore W2127176239C2777670902 @default.
• W2127176239 hasConceptScore W2127176239C2779134260 @default.
• W2127176239 hasConceptScore W2127176239C2780062018 @default.
• W2127176239 hasConceptScore W2127176239C2780647506 @default.
• W2127176239 hasConceptScore W2127176239C513476851 @default.

• next