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- W2130488473 abstract "THERE has been some controversy regarding the proper management of chronic idiopathic thrombocytopenic purpura (ITP) since 1950.<sup>1</sup>During this period, the treatment of choice has made a complete cycle. Initially, splenectomy was the only modality of treatment which produced a reasonable percentage of lasting remissions. Because of low remission rates in the 50% to 60% range, and because of the rather high mortality and morbidity of the procedure, the medical profession wished to find a more effective method of treatment. The discovery of the therapeutic benefits of corticosteroids in autoimmune disorders provided a possible solution. For several years steroids enjoyed popularity as the treatment of choice, and splenectomy was reserved only for those patients in whom long-term medical management failed. Unfortunately, prolonged remission rates with steroids were no higher than 35% to 50%.<sup>2</sup>In addition, the undesirable complications of long-term steroid therapy, namely, acne, osteoporosis, peptic ulceration, moon" @default.
- W2130488473 created "2016-06-24" @default.
- W2130488473 creator A5066955506 @default.
- W2130488473 date "1967-09-01" @default.
- W2130488473 modified "2023-10-17" @default.
- W2130488473 title "Splenectomy for Chronic Idiopathic Thrombocytopenic Purpura" @default.
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- W2130488473 doi "https://doi.org/10.1001/archsurg.1967.01330150020004" @default.
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