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• W2130672275 abstract "Neonatal hypoxic–ischemic encephalopathy (HIE) is one of the major causes of neurodegeneration and mortality in the neonatal period. Although hypoxic preconditioning (HPC) provided strong neuroprotection against HIE in an animal model, the mechanism underlying this effect is not fully understood especially in the immature brain. Here, we investigated whether thyroid hormones (THs), especially triiodothyronine (T3), which are essential during normal brain development, contribute to the neuroprotective mechanisms of HPC by using an established model of HPC in neonatal rats. HPC treatment (8% O2 for 2.5 h at 37 °C) was performed in immature rats at postnatal day 6 (P6). Subsequently, we investigated the levels of THs, TH receptors (TRs) and type 2 and 3 deiodinase (D2 and D3) mRNA, and glutamate transporter 1 (GLT1) at 24 h after HPC treatment, and myelin basic protein (MBP) at 6, 12 and 24 h after HPC treatment. The HIE procedure was performed at 24 h after HPC, and the neuroprotective effect of HPC was assessed via microtubule-associated protein 2 (MAP2) and MBP immunohistochemical staining at 14 days after HIE (P21). HPC treatment afforded marked neuroprotection at 14 days after HIE. The local level of T3 was upregulated 24 h after HPC treatment in the developing rat brain, probably via the upregulation of D2. In addition, the expression of MBP and GLT1, which are the downstream protein of T3, were significantly increased 24 h after HPC treatment. The present study indicates that thyroid hormones and their associated molecules may be involved in neuroprotective mechanisms of HPC during the developmental period." @default.
• W2130672275 created "2016-06-24" @default.
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• W2130672275 date "2013-03-01" @default.
• W2130672275 modified "2023-09-26" @default.
• W2130672275 title "Hypoxic preconditioning increases triiodothyronine (T3) level in the developing rat brain" @default.
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• W2130672275 doi "https://doi.org/10.1016/j.brainres.2013.01.036" @default.
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