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- W2135603552 abstract "The chemokine system has a critical role in mammalian immunity, but the evolutionary history of chemokines and chemokine receptors are ill-defined. We used comparative whole genome analysis of fruit fly, sea urchin, sea squirt, pufferfish, zebrafish, frog, and chicken to identify chemokines and chemokine receptors in each species. We report 127 chemokine and 70 chemokine receptor genes in the 7 species, with zebrafish having the most chemokines, 63, and chemokine receptors, 24. Fruit fly, sea urchin, and sea squirt have no identifiable chemokines or chemokine receptors. This study represents the most comprehensive analysis of the chemokine system to date and the only complete characterization of chemokine systems outside of mouse and human. We establish a clear evolutionary model of the chemokine system and trace the origin of the chemokine system to approximately 650 million years ago, identifying critical steps in their evolution and demonstrating a more extensive chemokine system in fish than previously thought." @default.
- W2135603552 created "2016-06-24" @default.
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- W2135603552 date "2006-01-01" @default.
- W2135603552 modified "2023-10-18" @default.
- W2135603552 title "Defining the Origins and Evolution of the Chemokine/Chemokine Receptor System" @default.
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- W2135603552 doi "https://doi.org/10.4049/jimmunol.176.1.401" @default.
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