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- W2148923308 abstract "The number of receptors opening after glutamate release is critical for understanding the sources of noise and the dynamic range of synaptic transmission. We imaged [Ca2+] transients mediated by synaptically activated NMDA receptors (NMDA-Rs) in individual spines in rat brain slices. We show that Ca2+ influx through single NMDA-Rs can be reliably detected, allowing us to estimate the number of receptors opening after synaptic transmission. This number is small: at the peak of the synaptic response, less than one NMDA-R is open, on average. Therefore, stochastic interactions between transmitter and receptor contribute substantially to synaptic noise, and glutamate occupies a small fraction of receptors. The number of receptors opening did not scale with spine volume, and smaller spines experience larger [Ca2+] transients during synaptic transmission. Our measurements further demonstrate that optical recordings can be used to study single receptors in intact systems." @default.
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- W2148923308 date "2004-02-25" @default.
- W2148923308 modified "2023-10-16" @default.
- W2148923308 title "The Number of Glutamate Receptors Opened by Synaptic Stimulation in Single Hippocampal Spines" @default.
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- W2148923308 doi "https://doi.org/10.1523/jneurosci.5066-03.2004" @default.
- W2148923308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6730404" @default.
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