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• W2149452000 abstract "The recent exponential increase in our knowledge of cellular and molecular mechanisms involved in carcinogenesis has largely failed to translate into new therapies and clinical practices. This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug potentials, as well as a poor understanding of tumor microenvironment in diagnosis and prognosis leads to the current levels of treatment failure regarding a vast majority of cancer types. A growing body of evidence points to the importance of the functional diversity of immune and structural cells during tumor development. In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy." @default.
• W2149452000 created "2016-06-24" @default.
• W2149452000 creator A5001112378 @default.
• W2149452000 creator A5001924735 @default.
• W2149452000 creator A5044947102 @default.
• W2149452000 creator A5059967673 @default.
• W2149452000 creator A5081991438 @default.
• W2149452000 date "2015-07-31" @default.
• W2149452000 modified "2023-10-15" @default.
• W2149452000 title "Genetic instability in the tumor microenvironment: a new look at an old neighbor" @default.
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