Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153166763> ?p ?o ?g. }
- W2153166763 endingPage "1142" @default.
- W2153166763 startingPage "1112" @default.
- W2153166763 abstract "G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately, mutations and dysregulation of GPCRs that induce a loss of function or alter expression can lead to disorders that are sometimes lethal. Therefore, the expression, trafficking, signaling and desensitization of GPCRs must be tightly regulated by different cellular systems to prevent disease. Although there is substantial knowledge regarding the mechanisms that regulate the desensitization and down-regulation of GPCRs, less is known about the mechanisms that regulate the trafficking and cell-surface expression of newly synthesized GPCRs. More recently, there is accumulating evidence that suggests certain GPCRs are able to interact with specific proteins that can completely change their fate and function. These interactions add on another level of regulation and flexibility between different tissue/cell-types. Here, we review some of the main interacting proteins of GPCRs. A greater understanding of the mechanisms regulating their interactions may lead to the discovery of new drug targets for therapy." @default.
- W2153166763 created "2016-06-24" @default.
- W2153166763 creator A5011596226 @default.
- W2153166763 creator A5044700522 @default.
- W2153166763 date "2014-01-16" @default.
- W2153166763 modified "2023-10-16" @default.
- W2153166763 title "G Protein-Coupled Receptors: What a Difference a ‘Partner’ Makes" @default.
- W2153166763 cites W1507084693 @default.
- W2153166763 cites W1527823690 @default.
- W2153166763 cites W1535107724 @default.
- W2153166763 cites W1562745957 @default.
- W2153166763 cites W1562767954 @default.
- W2153166763 cites W1567413936 @default.
- W2153166763 cites W1599561836 @default.
- W2153166763 cites W1619426618 @default.
- W2153166763 cites W1897165783 @default.
- W2153166763 cites W1909076506 @default.
- W2153166763 cites W1952027208 @default.
- W2153166763 cites W1963770237 @default.
- W2153166763 cites W1964557313 @default.
- W2153166763 cites W1966398753 @default.
- W2153166763 cites W1967060390 @default.
- W2153166763 cites W1969059511 @default.
- W2153166763 cites W1971863163 @default.
- W2153166763 cites W1975075811 @default.
- W2153166763 cites W1976875808 @default.
- W2153166763 cites W1979199686 @default.
- W2153166763 cites W1979353935 @default.
- W2153166763 cites W1979420492 @default.
- W2153166763 cites W1981578013 @default.
- W2153166763 cites W1981653194 @default.
- W2153166763 cites W1981977135 @default.
- W2153166763 cites W1983908525 @default.
- W2153166763 cites W1985194414 @default.
- W2153166763 cites W1987194328 @default.
- W2153166763 cites W1988715808 @default.
- W2153166763 cites W1991148544 @default.
- W2153166763 cites W1993185022 @default.
- W2153166763 cites W1995586699 @default.
- W2153166763 cites W1996333756 @default.
- W2153166763 cites W1996836065 @default.
- W2153166763 cites W1997270590 @default.
- W2153166763 cites W1999591184 @default.
- W2153166763 cites W2000272692 @default.
- W2153166763 cites W2001101134 @default.
- W2153166763 cites W2002527589 @default.
- W2153166763 cites W2003370087 @default.
- W2153166763 cites W2003546418 @default.
- W2153166763 cites W2004051792 @default.
- W2153166763 cites W2004361183 @default.
- W2153166763 cites W2004911098 @default.
- W2153166763 cites W2005252392 @default.
- W2153166763 cites W2005672588 @default.
- W2153166763 cites W2008186223 @default.
- W2153166763 cites W2009411531 @default.
- W2153166763 cites W2009504616 @default.
- W2153166763 cites W2012040490 @default.
- W2153166763 cites W2013111477 @default.
- W2153166763 cites W2015137255 @default.
- W2153166763 cites W2015256174 @default.
- W2153166763 cites W2015922146 @default.
- W2153166763 cites W201847332 @default.
- W2153166763 cites W2018717551 @default.
- W2153166763 cites W2022535425 @default.
- W2153166763 cites W2022735531 @default.
- W2153166763 cites W2023079616 @default.
- W2153166763 cites W2023917526 @default.
- W2153166763 cites W2026669832 @default.
- W2153166763 cites W2027662766 @default.
- W2153166763 cites W2029474878 @default.
- W2153166763 cites W2030614715 @default.
- W2153166763 cites W2030794189 @default.
- W2153166763 cites W2031232612 @default.
- W2153166763 cites W2032665022 @default.
- W2153166763 cites W2032795118 @default.
- W2153166763 cites W2034836489 @default.
- W2153166763 cites W2035036972 @default.
- W2153166763 cites W2035770843 @default.
- W2153166763 cites W2035917312 @default.
- W2153166763 cites W2037710668 @default.
- W2153166763 cites W2038594983 @default.
- W2153166763 cites W2038930756 @default.
- W2153166763 cites W2043216372 @default.
- W2153166763 cites W2044285853 @default.
- W2153166763 cites W2045893780 @default.
- W2153166763 cites W2046763041 @default.
- W2153166763 cites W2047316114 @default.
- W2153166763 cites W2047458612 @default.
- W2153166763 cites W2047841437 @default.
- W2153166763 cites W2047896617 @default.
- W2153166763 cites W2048935574 @default.
- W2153166763 cites W2049876031 @default.
- W2153166763 cites W2050347424 @default.
- W2153166763 cites W2050620941 @default.
- W2153166763 cites W2055242244 @default.
- W2153166763 cites W2055267308 @default.
- W2153166763 cites W2056442594 @default.
- W2153166763 cites W2057468474 @default.