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- W2154084570 abstract "Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine." @default.
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- W2154084570 date "1968-12-13" @default.
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- W2154084570 title "Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine" @default.
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- W2154084570 doi "https://doi.org/10.1126/science.162.3859.1290" @default.
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