FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155341876> ?p ?o ?g. }

• W2155341876 endingPage "1106" @default.
• W2155341876 startingPage "1095" @default.
• W2155341876 abstract "The role of Syk kinase in Fc gamma receptor (Fc gamma R) IIA-mediated phagocytosis was examined with two forms of antisense oligodeoxynucleotides (ODNs) designed to hybridize to human Syk mRNA. Monocytes were incubated with linear and stem-loop antisense ODNs targeted to Syk mRNA. When complexed with cationic liposomes, stem-loop Syk antisense ODN with phosphorothioate modification exhibited stability in fetal bovine and human serum. The stem-loop Syk antisense ODN at a concentration of 0.2 microM inhibited Fc gamma RIIA-mediated phagocytosis by 90% and completely eliminated Syk mRNA and protein in monocytes, whereas scrambled-control ODNs had no effect. The Syk antisense ODNs did not change beta-actin mRNA levels and Fc gamma RII cell-surface expression. In addition, stem-loop Syk antisense ODN inhibited Fc gamma RI and Fc gamma RIIIA-mediated phagocytosis. These data indicate the efficacy of stem-loop Syk antisense ODN for targeting and degrading Syk mRNA and protein and the importance of Syk kinase in Fc gamma receptor-mediated phagocytosis. Immunoblotting assay demonstrated that Fc gamma RII tyrosine phosphorylation after Fc gamma RII cross-linking did not change in the absence of Syk protein. These results indicate that Syk kinase is required for Fc gamma RIIA-mediated phagocytic signaling and that Fc gamma RII cross-linking leads to tyrosine phosphorylation of Fc gamma RII independent of Syk kinase." @default.
• W2155341876 created "2016-06-24" @default.
• W2155341876 creator A5008503571 @default.
• W2155341876 creator A5024525935 @default.
• W2155341876 creator A5037221383 @default.
• W2155341876 creator A5051292169 @default.
• W2155341876 creator A5060610428 @default.
• W2155341876 creator A5089560915 @default.
• W2155341876 date "1996-07-01" @default.
• W2155341876 modified "2023-10-16" @default.
• W2155341876 title "Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides." @default.
• W2155341876 cites W106950157 @default.
• W2155341876 cites W147011734 @default.
• W2155341876 cites W1481629090 @default.
• W2155341876 cites W1510771719 @default.
• W2155341876 cites W1525901333 @default.
• W2155341876 cites W1530177683 @default.
• W2155341876 cites W1533457677 @default.
• W2155341876 cites W1540088669 @default.
• W2155341876 cites W1545383294 @default.
• W2155341876 cites W1569129572 @default.
• W2155341876 cites W1605822460 @default.
• W2155341876 cites W1608689696 @default.
• W2155341876 cites W1627731841 @default.
• W2155341876 cites W165036993 @default.
• W2155341876 cites W1752221293 @default.
• W2155341876 cites W1878715199 @default.
• W2155341876 cites W1970650788 @default.
• W2155341876 cites W1979876932 @default.
• W2155341876 cites W1981481692 @default.
• W2155341876 cites W1986549185 @default.
• W2155341876 cites W1999949426 @default.
• W2155341876 cites W2006239014 @default.
• W2155341876 cites W2007163229 @default.
• W2155341876 cites W2016738490 @default.
• W2155341876 cites W2034645623 @default.
• W2155341876 cites W2035439001 @default.
• W2155341876 cites W2047385558 @default.
• W2155341876 cites W2050014764 @default.
• W2155341876 cites W2052896363 @default.
• W2155341876 cites W2069125860 @default.
• W2155341876 cites W2072488277 @default.
• W2155341876 cites W2089865395 @default.
• W2155341876 cites W2122200639 @default.
• W2155341876 cites W2183656856 @default.
• W2155341876 cites W2397307770 @default.
• W2155341876 cites W2413658434 @default.
• W2155341876 cites W2418257162 @default.
• W2155341876 cites W2425249855 @default.
• W2155341876 cites W2471997762 @default.
• W2155341876 cites W4249736906 @default.
• W2155341876 cites W71826833 @default.
• W2155341876 doi "https://doi.org/10.1091/mbc.7.7.1095" @default.
• W2155341876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/275961" @default.
• W2155341876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8862523" @default.
• W2155341876 hasPublicationYear "1996" @default.
• W2155341876 type Work @default.
• W2155341876 sameAs 2155341876 @default.
• W2155341876 citedByCount "100" @default.
• W2155341876 countsByYear W21553418762012 @default.
• W2155341876 countsByYear W21553418762013 @default.
• W2155341876 countsByYear W21553418762014 @default.
• W2155341876 countsByYear W21553418762015 @default.
• W2155341876 countsByYear W21553418762017 @default.
• W2155341876 countsByYear W21553418762019 @default.
• W2155341876 countsByYear W21553418762020 @default.
• W2155341876 countsByYear W21553418762023 @default.
• W2155341876 crossrefType "journal-article" @default.
• W2155341876 hasAuthorship W2155341876A5008503571 @default.
• W2155341876 hasAuthorship W2155341876A5024525935 @default.
• W2155341876 hasAuthorship W2155341876A5037221383 @default.
• W2155341876 hasAuthorship W2155341876A5051292169 @default.
• W2155341876 hasAuthorship W2155341876A5060610428 @default.
• W2155341876 hasAuthorship W2155341876A5089560915 @default.
• W2155341876 hasBestOaLocation W21553418762 @default.
• W2155341876 hasConcept C153911025 @default.
• W2155341876 hasConcept C160448771 @default.
• W2155341876 hasConcept C170493617 @default.
• W2155341876 hasConcept C184235292 @default.
• W2155341876 hasConcept C2777553839 @default.
• W2155341876 hasConcept C35174551 @default.
• W2155341876 hasConcept C42362537 @default.
• W2155341876 hasConcept C55493867 @default.
• W2155341876 hasConcept C62478195 @default.
• W2155341876 hasConcept C86803240 @default.
• W2155341876 hasConcept C95444343 @default.
• W2155341876 hasConceptScore W2155341876C153911025 @default.
• W2155341876 hasConceptScore W2155341876C160448771 @default.
• W2155341876 hasConceptScore W2155341876C170493617 @default.
• W2155341876 hasConceptScore W2155341876C184235292 @default.
• W2155341876 hasConceptScore W2155341876C2777553839 @default.
• W2155341876 hasConceptScore W2155341876C35174551 @default.
• W2155341876 hasConceptScore W2155341876C42362537 @default.
• W2155341876 hasConceptScore W2155341876C55493867 @default.
• W2155341876 hasConceptScore W2155341876C62478195 @default.
• W2155341876 hasConceptScore W2155341876C86803240 @default.
• W2155341876 hasConceptScore W2155341876C95444343 @default.
• W2155341876 hasIssue "7" @default.

• next