FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157002015> ?p ?o ?g. }

• W2157002015 endingPage "920" @default.
• W2157002015 startingPage "911" @default.
• W2157002015 abstract "Epileptiform discharges are known to reflect the hypersynchronous glutamatergic activation of cortical neurons. However, experimental evidence has revealed that epileptiform synchronization is also contributed to by population events mediated by GABAA receptors. Here, we analysed the spatial distribution of GABAA-receptor-dependent interictal events in the hippocampal/parahippocampal region of the adult guinea pig brain isolated in vitro. We found that arterial perfusion of this preparation with 4-aminopyridine caused the appearance of glutamatergic-independent interictal potentials that were reversibly abolished by GABAA receptor antagonism. Laminar profiles and current source density analysis performed in different limbic areas demonstrated that these GABAA-receptor-mediated events were independently generated in different areas of the hippocampal/parahippocampal formation (most often in the medial entorhinal cortex) and propagated between interconnected limbic structures of both hemispheres. Finally, intracellular recordings from principal neurons of the medial entorhinal cortex demonstrated that the GABAergic field potential correlated to inhibitory postsynaptic potentials (membrane potential reversal, −68.12 ± 8.01 mV, n = 5) that were interrupted by ectopic spiking. Our findings demonstrate that, in an acute seizure model developed in the adult guinea pig brain, hypersynchronous GABAA-receptor-mediated interictal events are generated from independent sources and propagate within limbic cortices in the absence of excitatory synaptic transmission. As spared or enhanced inhibition was reported in models of epilepsy, our data may support a role of GABA-mediated signaling in ictogenesis and epileptogenesis." @default.
• W2157002015 created "2016-06-24" @default.
• W2157002015 creator A5007468350 @default.
• W2157002015 creator A5027294480 @default.
• W2157002015 creator A5032087424 @default.
• W2157002015 date "2009-03-01" @default.
• W2157002015 modified "2023-10-16" @default.
• W2157002015 title "Synchronous GABA_A-receptor-dependent potentials in limbic areas of the<i>in-vitro</i>isolated adult guinea pig brain" @default.
• W2157002015 cites W1036148449 @default.
• W2157002015 cites W1219807308 @default.
• W2157002015 cites W1501375812 @default.
• W2157002015 cites W1520163941 @default.
• W2157002015 cites W1555946311 @default.
• W2157002015 cites W1565624927 @default.
• W2157002015 cites W1764994580 @default.
• W2157002015 cites W1774260123 @default.
• W2157002015 cites W188749348 @default.
• W2157002015 cites W1963710870 @default.
• W2157002015 cites W1970412478 @default.
• W2157002015 cites W1978929982 @default.
• W2157002015 cites W1981068197 @default.
• W2157002015 cites W1995441615 @default.
• W2157002015 cites W1997566072 @default.
• W2157002015 cites W2000650034 @default.
• W2157002015 cites W2001574400 @default.
• W2157002015 cites W2007628754 @default.
• W2157002015 cites W2007773833 @default.
• W2157002015 cites W2009332732 @default.
• W2157002015 cites W2010817672 @default.
• W2157002015 cites W2011137107 @default.
• W2157002015 cites W2011318716 @default.
• W2157002015 cites W2012540766 @default.
• W2157002015 cites W2013273834 @default.
• W2157002015 cites W2019357760 @default.
• W2157002015 cites W2024343314 @default.
• W2157002015 cites W2027141849 @default.
• W2157002015 cites W2027661077 @default.
• W2157002015 cites W2028452463 @default.
• W2157002015 cites W2042196629 @default.
• W2157002015 cites W2047445554 @default.
• W2157002015 cites W2059754952 @default.
• W2157002015 cites W2067239852 @default.
• W2157002015 cites W2069586118 @default.
• W2157002015 cites W2093621498 @default.
• W2157002015 cites W2093840338 @default.
• W2157002015 cites W2101907550 @default.
• W2157002015 cites W2106985452 @default.
• W2157002015 cites W2114091591 @default.
• W2157002015 cites W2120278577 @default.
• W2157002015 cites W2130630814 @default.
• W2157002015 cites W2131046634 @default.
• W2157002015 cites W2137924205 @default.
• W2157002015 cites W2141468617 @default.
• W2157002015 cites W2143998666 @default.
• W2157002015 cites W2162418003 @default.
• W2157002015 cites W2163697953 @default.
• W2157002015 cites W2204516377 @default.
• W2157002015 cites W2222396702 @default.
• W2157002015 cites W2261008854 @default.
• W2157002015 cites W2409505568 @default.
• W2157002015 cites W2414559620 @default.
• W2157002015 cites W2444670246 @default.
• W2157002015 cites W4322701228 @default.
• W2157002015 doi "https://doi.org/10.1111/j.1460-9568.2009.06672.x" @default.
• W2157002015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4873282" @default.
• W2157002015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19291222" @default.
• W2157002015 hasPublicationYear "2009" @default.
• W2157002015 type Work @default.
• W2157002015 sameAs 2157002015 @default.
• W2157002015 citedByCount "37" @default.
• W2157002015 countsByYear W21570020152012 @default.
• W2157002015 countsByYear W21570020152013 @default.
• W2157002015 countsByYear W21570020152014 @default.
• W2157002015 countsByYear W21570020152015 @default.
• W2157002015 countsByYear W21570020152016 @default.
• W2157002015 countsByYear W21570020152017 @default.
• W2157002015 countsByYear W21570020152018 @default.
• W2157002015 countsByYear W21570020152019 @default.
• W2157002015 countsByYear W21570020152021 @default.
• W2157002015 countsByYear W21570020152022 @default.
• W2157002015 countsByYear W21570020152023 @default.
• W2157002015 crossrefType "journal-article" @default.
• W2157002015 hasAuthorship W2157002015A5007468350 @default.
• W2157002015 hasAuthorship W2157002015A5027294480 @default.
• W2157002015 hasAuthorship W2157002015A5032087424 @default.
• W2157002015 hasBestOaLocation W21570020152 @default.
• W2157002015 hasConcept C112592302 @default.
• W2157002015 hasConcept C148762608 @default.
• W2157002015 hasConcept C168258287 @default.
• W2157002015 hasConcept C169760540 @default.
• W2157002015 hasConcept C170493617 @default.
• W2157002015 hasConcept C17077164 @default.
• W2157002015 hasConcept C17755696 @default.
• W2157002015 hasConcept C185592680 @default.
• W2157002015 hasConcept C200170125 @default.
• W2157002015 hasConcept C2778186239 @default.
• W2157002015 hasConcept C2779177108 @default.
• W2157002015 hasConcept C2780648746 @default.

• next