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• W2159232816 abstract "Clostridium difficile, a leading cause of hospital-acquired bacterial infection, is coated in a dense surface layer (S-layer) that is thought to provide both physicochemical protection and a scaffold for host-pathogen interactions. The key structural components of the S-layer are two proteins derived from a polypeptide precursor, SlpA, via proteolytic cleavage by the protease Cwp84. Here, we report the design, synthesis and in vivo characterization of a panel of protease inhibitors and activity-based probes (ABPs) designed to target S-layer processing in live C. difficile cells. Inhibitors based on substrate-mimetic peptides bearing a C-terminal Michael acceptor warhead were found to be promising candidates for further development." @default.
• W2159232816 created "2016-06-24" @default.
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• W2159232816 date "2012-01-01" @default.
• W2159232816 modified "2023-10-09" @default.
• W2159232816 title "Novel inhibitors of surface layer processing in Clostridium difficile" @default.
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• W2159232816 doi "https://doi.org/10.1016/j.bmc.2011.06.042" @default.
• W2159232816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21752656" @default.
• W2159232816 hasPublicationYear "2012" @default.
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