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• W2169722936 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2004Dietary L-Arginine Supplementation Improves the Glomerular Filtration Rate and Renal Blood Flow After 24 Hours of Unilateral Ureteral Obstruction in Rats KEIICHI ITO, JIE CHEN, E. DARRACOTT VAUGHAN, SURYA V. SESHAN, DIX P. POPPAS, and DIANE FELSEN KEIICHI ITOKEIICHI ITO More articles by this author , JIE CHENJIE CHEN More articles by this author , E. DARRACOTT VAUGHANE. DARRACOTT VAUGHAN More articles by this author , SURYA V. SESHANSURYA V. SESHAN More articles by this author , DIX P. POPPASDIX P. POPPAS More articles by this author , and DIANE FELSENDIANE FELSEN More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000105073.67242.ebAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Unilateral ureteral obstruction (UUO) results in a significant change in renal blood flow (RBF) and glomerular filtration rate (GFR) by 24 hours. The intake of L-arginine, a substrate of nitric oxide (NO) synthase (NOS), can augment NO production. NO can maintain renal function through its vasodilatory action. Therefore, we examined the effect of dietary arginine supplementation on renal function in UUO. Materials and Methods: GFR and RBF were measured by inulin and para-aminohippurate clearance, respectively, in control rats and in rats 24 hours after UUO. Rats were given arginine with or without the concomitant administration of N-nitro-L-arginine methyl ester. Urinary nitrate/nitrite (NO2/NO3) was measured by the Griess reaction and urinary cyclic guanosine monophosphate was determined by enzyme-linked immunosorbent assay. The expression of renal inducible NOS was determined by immunohistochemistry. Results: Urinary NO2/NO3 was significantly increased after 2 weeks of arginine, confirming increased NO production. In control rats GFR and RBF were not significantly different in untreated vs arginine treated groups. In contrast, arginine treatment significantly increased GFR in the obstructed kidney (0.06 ± 0.01 to 0.14 ± 0.02 ml per minute per 100 gm) and the contralateral kidney compared with control UUO. RBF was also significantly increased by arginine. The increases in renal function with arginine were blunted by a NOS inhibitor in obstructed and contralateral kidneys. Inducible NOS expression was increased in obstructed and contralateral kidneys. Conclusions: This study demonstrates that L-arginine supplementation can improve renal function in acute UUO. This finding suggests that NO system may be a future site of pharmacological intervention for UUO. References 1 : Pathophysiology of urinary tract obstruction. In: . Philadelphia: W. B. Saunders Co.2002. chapt. 12. Google Scholar 2 : Comparison of the renal hemodynamic response to unilateral and bilateral ureteral occlusion. Invest Urol1977; 14: 455. Google Scholar 3 : Nitric oxide 9 years on. J R Soc Med1996; 89: 667. Crossref, Medline, Google Scholar 4 : Renal hemodynamics and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide. J Urol2003; 169: 373. Abstract, Google Scholar 5 : Nitric oxide in unilateral ureteral obstruction: effect on regional renal blood flow. Kidney Int2001; 59: 10591. Google Scholar 6 : Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction. Kidney Int2001; 59: 1290. 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Google Scholar From the Institute for Pediatric Urology, Department of Urology, New York Presbyterian Children's Hospital (KI, JC, DPP, EDV, DF) and Department of Pathology, New York Presbyterian Hospital (SVS), Weill Cornell Medical College, New York, New York© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byIto K, Yoshii H, Asano T, Seta K, Mizuguchi Y, Yamanaka M, Tokonabe S, Hayakawa M and Asano T (2010) Adrenomedullin Increases Renal Nitric Oxide Production and Ameliorates Renal Injury in Mice With Unilateral Ureteral ObstructionJournal of Urology, VOL. 183, NO. 4, (1630-1635), Online publication date: 1-Apr-2010.VAUGHAN E, MARION D, POPPAS D and FELSEN D (2018) PATHOPHYSIOLOGY OF UNILATERAL URETERAL OBSTRUCTION: STUDIES FROM CHARLOTTESVILLE TO NEW YORKJournal of Urology, VOL. 172, NO. 6 Part 2, (2563-2569), Online publication date: 1-Dec-2004. Volume 171Issue 2February 2004Page: 926-930 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsureteral obstructionnitric oxideureterkidneyrenal circulationMetrics Author Information KEIICHI ITO More articles by this author JIE CHEN More articles by this author E. DARRACOTT VAUGHAN More articles by this author SURYA V. SESHAN More articles by this author DIX P. POPPAS More articles by this author DIANE FELSEN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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