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• W2169772648 abstract "Speakers Bureau: AxoGen, Inc. (Safa, Buncke)Contracted Research: Axogen (Thayer, Buncke)HypothesisThe historical standard for peripheral nerve gap repair has been the nerve autograft. Recently processed nerve allografts have been established as a viable alternative. To examine the differences we added contemporary control cohorts to a national nerve registry. Based on scientific evidence and historical controls, we hypothesized that processed nerve allografts would perform similar to nerve autograft in mixed nerve injuries of the upper extremity.MethodsThe RANGER registry is an active database designed to collect injury, repair, safety and outcomes data for processed nerve allografts (Avance® Nerve Graft, AxoGen, Inc) according to an IRB approved protocol. Contemporary controls added to the established registry allow for comparisons of recovery outcomes between treatment groups. The database was queried for subjects presenting with mixed nerve gap injuries up to 70 mm repaired with either processed nerve allograft (PNA) or nerve autograft. Identified subjects reporting quantitative outcomes with a minimum of nine months follow up were included in the dataset. Subject demographics and repair characteristics, and recovery of function were compared. Meaningful recovery was defined as S3/M3 or greater (MRCC scale).ResultsTwenty subjects with 22 injuries were included. The groups consisted of PNA (n=14) and nerve autograft (n=8). Subject demographics, medical history, and concomitant injuries were comparable between treatment groups. The PNA group reported a higher incidence of high energy traumatic injuries. Repair techniques varied between the groups. The PNA repairs included size matched fascicular or caliber matched epineural repairs while all the nerve autografts were multi-strand cabled repairs. The average nerve gap between the groups varied at 30+14 mm and 44+11 mm for PNA and nerve autograft respectively. Available quantitative data reported meaningful recovery in 86% in PNA group as compared to 88% for nerve autograft. See Table 1 for a summary of treatment groups. See Figure 2 for a distribution of sensory and motor MRCC scores by repair group. There were no reported adverse events related to the treatment groups.Summary PointsView Large Image Figure ViewerDownload Hi-res image Download (PPT) Speakers Bureau: AxoGen, Inc. (Safa, Buncke)Contracted Research: Axogen (Thayer, Buncke) HypothesisThe historical standard for peripheral nerve gap repair has been the nerve autograft. Recently processed nerve allografts have been established as a viable alternative. To examine the differences we added contemporary control cohorts to a national nerve registry. Based on scientific evidence and historical controls, we hypothesized that processed nerve allografts would perform similar to nerve autograft in mixed nerve injuries of the upper extremity. The historical standard for peripheral nerve gap repair has been the nerve autograft. Recently processed nerve allografts have been established as a viable alternative. To examine the differences we added contemporary control cohorts to a national nerve registry. Based on scientific evidence and historical controls, we hypothesized that processed nerve allografts would perform similar to nerve autograft in mixed nerve injuries of the upper extremity. MethodsThe RANGER registry is an active database designed to collect injury, repair, safety and outcomes data for processed nerve allografts (Avance® Nerve Graft, AxoGen, Inc) according to an IRB approved protocol. Contemporary controls added to the established registry allow for comparisons of recovery outcomes between treatment groups. The database was queried for subjects presenting with mixed nerve gap injuries up to 70 mm repaired with either processed nerve allograft (PNA) or nerve autograft. Identified subjects reporting quantitative outcomes with a minimum of nine months follow up were included in the dataset. Subject demographics and repair characteristics, and recovery of function were compared. Meaningful recovery was defined as S3/M3 or greater (MRCC scale). The RANGER registry is an active database designed to collect injury, repair, safety and outcomes data for processed nerve allografts (Avance® Nerve Graft, AxoGen, Inc) according to an IRB approved protocol. Contemporary controls added to the established registry allow for comparisons of recovery outcomes between treatment groups. The database was queried for subjects presenting with mixed nerve gap injuries up to 70 mm repaired with either processed nerve allograft (PNA) or nerve autograft. Identified subjects reporting quantitative outcomes with a minimum of nine months follow up were included in the dataset. Subject demographics and repair characteristics, and recovery of function were compared. Meaningful recovery was defined as S3/M3 or greater (MRCC scale). ResultsTwenty subjects with 22 injuries were included. The groups consisted of PNA (n=14) and nerve autograft (n=8). Subject demographics, medical history, and concomitant injuries were comparable between treatment groups. The PNA group reported a higher incidence of high energy traumatic injuries. Repair techniques varied between the groups. The PNA repairs included size matched fascicular or caliber matched epineural repairs while all the nerve autografts were multi-strand cabled repairs. The average nerve gap between the groups varied at 30+14 mm and 44+11 mm for PNA and nerve autograft respectively. Available quantitative data reported meaningful recovery in 86% in PNA group as compared to 88% for nerve autograft. See Table 1 for a summary of treatment groups. See Figure 2 for a distribution of sensory and motor MRCC scores by repair group. There were no reported adverse events related to the treatment groups. Twenty subjects with 22 injuries were included. The groups consisted of PNA (n=14) and nerve autograft (n=8). Subject demographics, medical history, and concomitant injuries were comparable between treatment groups. The PNA group reported a higher incidence of high energy traumatic injuries. Repair techniques varied between the groups. The PNA repairs included size matched fascicular or caliber matched epineural repairs while all the nerve autografts were multi-strand cabled repairs. The average nerve gap between the groups varied at 30+14 mm and 44+11 mm for PNA and nerve autograft respectively. Available quantitative data reported meaningful recovery in 86% in PNA group as compared to 88% for nerve autograft. See Table 1 for a summary of treatment groups. See Figure 2 for a distribution of sensory and motor MRCC scores by repair group. There were no reported adverse events related to the treatment groups. Summary Points" @default.
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• W2169772648 date "2015-09-01" @default.
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• W2169772648 title "Evaluation of Outcomes from Processed Nerve Allograft and Nerve Autograft Repairs in Upper Extremity Mixed Nerve Injuries" @default.
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