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- W2170817723 abstract "Three types of opioid receptors (ORs: mu [μ], kappa [k], and delta [δ]) are differentially distributed throughout the brain. Historically, the |μOR has been of great est clinical interest because it mediates therapeutic effects (e.g., analgesia and cough suppression) and nontherapeutic effects (e.g., abuse and physical dependence) of opioid agonists. This “dual-edged sword” underlies the classical dilemma of balanc ing safety and efficacy when |μOR agonists are administered systemically to human subjects. Preclinical studies suggest that kOR- and δOR-specific agonists and antago nists could be useful in treating human substance use disorders, but the lack of such Food and Drug Administration (FDA)-approved medications significantly limits our understanding of the role of these molecular targets in the clinical setting. However, the μμOR-specific radiotracer [11C]-carfentanil has been used with positron emission tomography (PET) to elucidate the function of this endogenous system as it relates to substance use disorders, both with antagonists (e.g., naltrexone) and agonists (e.g., buprenorphine). The δOR-specific tracer [11C]-methyl-naltrindole is also available for human use, but has not yet been applied to substance use disorders, and a kOR-specific tracer has shown promise in preclinical testing. Advances in neuroscience and medication development are likely to yield significant progress that will improve our understanding of these disorders and clinical outcomes in the near future." @default.
- W2170817723 created "2016-06-24" @default.
- W2170817723 creator A5024100091 @default.
- W2170817723 creator A5063230735 @default.
- W2170817723 date "2009-01-01" @default.
- W2170817723 modified "2023-09-23" @default.
- W2170817723 title "Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders" @default.
- W2170817723 cites W1818115547 @default.
- W2170817723 cites W1858569662 @default.
- W2170817723 cites W1946687472 @default.
- W2170817723 cites W1963890019 @default.
- W2170817723 cites W1966414084 @default.
- W2170817723 cites W1966622662 @default.
- W2170817723 cites W1967859700 @default.
- W2170817723 cites W1971213246 @default.
- W2170817723 cites W1971533804 @default.
- W2170817723 cites W1971962043 @default.
- W2170817723 cites W1977436056 @default.
- W2170817723 cites W1978251406 @default.
- W2170817723 cites W1978918042 @default.
- W2170817723 cites W1979023188 @default.
- W2170817723 cites W1980637329 @default.
- W2170817723 cites W1981860915 @default.
- W2170817723 cites W1983587230 @default.
- W2170817723 cites W1984010207 @default.
- W2170817723 cites W1985094131 @default.
- W2170817723 cites W1990684042 @default.
- W2170817723 cites W1992677947 @default.
- W2170817723 cites W1992731142 @default.
- W2170817723 cites W1993490516 @default.
- W2170817723 cites W1996646070 @default.
- W2170817723 cites W1999721002 @default.
- W2170817723 cites W2000149891 @default.
- W2170817723 cites W2000321144 @default.
- W2170817723 cites W2001345670 @default.
- W2170817723 cites W2002129794 @default.
- W2170817723 cites W2002335692 @default.
- W2170817723 cites W2003639454 @default.
- W2170817723 cites W2003714509 @default.
- W2170817723 cites W2004206878 @default.
- W2170817723 cites W2004215190 @default.
- W2170817723 cites W2008130303 @default.
- W2170817723 cites W2009082044 @default.
- W2170817723 cites W2009737470 @default.
- W2170817723 cites W2013107513 @default.
- W2170817723 cites W2016124588 @default.
- W2170817723 cites W2016194465 @default.
- W2170817723 cites W2016589872 @default.
- W2170817723 cites W2019871200 @default.
- W2170817723 cites W2020254877 @default.
- W2170817723 cites W2025482402 @default.
- W2170817723 cites W2026601485 @default.
- W2170817723 cites W2028806301 @default.
- W2170817723 cites W2029007163 @default.
- W2170817723 cites W2029330796 @default.
- W2170817723 cites W2029578188 @default.
- W2170817723 cites W2029741974 @default.
- W2170817723 cites W2029913530 @default.
- W2170817723 cites W2030177235 @default.
- W2170817723 cites W2032216247 @default.
- W2170817723 cites W2032434244 @default.
- W2170817723 cites W2033361664 @default.
- W2170817723 cites W2033519360 @default.
- W2170817723 cites W2036136942 @default.
- W2170817723 cites W2036302580 @default.
- W2170817723 cites W2036517132 @default.
- W2170817723 cites W2040327352 @default.
- W2170817723 cites W2041405553 @default.
- W2170817723 cites W2041982973 @default.
- W2170817723 cites W2044236275 @default.
- W2170817723 cites W2045284958 @default.
- W2170817723 cites W2045341302 @default.
- W2170817723 cites W2045960840 @default.
- W2170817723 cites W2046045427 @default.
- W2170817723 cites W2047379400 @default.
- W2170817723 cites W2051746492 @default.
- W2170817723 cites W2052630265 @default.
- W2170817723 cites W2052905392 @default.
- W2170817723 cites W2056145688 @default.
- W2170817723 cites W2063749627 @default.
- W2170817723 cites W2064447463 @default.
- W2170817723 cites W2065344935 @default.
- W2170817723 cites W2067020336 @default.
- W2170817723 cites W2069269138 @default.
- W2170817723 cites W2069370792 @default.
- W2170817723 cites W2070598281 @default.
- W2170817723 cites W2071497507 @default.
- W2170817723 cites W2072382900 @default.
- W2170817723 cites W2072807884 @default.
- W2170817723 cites W2073398764 @default.
- W2170817723 cites W2073483676 @default.
- W2170817723 cites W2074406420 @default.
- W2170817723 cites W2075715526 @default.
- W2170817723 cites W2075879521 @default.
- W2170817723 cites W2076381248 @default.
- W2170817723 cites W2079339983 @default.
- W2170817723 cites W2079975546 @default.
- W2170817723 cites W2085146359 @default.