FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2184320902> ?p ?o ?g. }

• W2184320902 abstract "Suo Quan Wan (SQW) is a Chinese traditional prescription that has been used in clinical treatment of lower urinary tract symptoms for centuries. However, scientific basis of SQW efficacy and mechanism is still needed. This study investigated the effect of SQW on bladder function and transient receptor potential vanilloid 1 (TRPV1) expression in the bladder of rats with bladder outlet obstruction (BOO). The induced changes in bladder function in overactive bladder (OAB) rat model were observed following different periods of outlet obstruction to obtain an appropriate rat model.This study was carried out in two parts. In the first part, female Sprague-Dawley rats received sham operations or partial BOO operations. Two, four, and six weeks later, the OAB model groups and control were subjected to urodynamic tests to measure differences in bladder functions. Once the appropriate rat model was obtained, the second part of the experiment was performed. The rat model was recreated and treated with SQW. Urodynamic assessment was conducted, and the bladders of the rats were then removed. Immunofluorescence staining, real-time PCR, and Western blot were performed to localize and quantify the expression of TRPV1 in the bladder.Results of the first part indicated that at 2 and 4 weeks, the OAB model group exhibited significant differences in urodynamic parameters, including bladder pressure, maximum voiding pressure, and maximum bladder capacity, compared with the sham group. At 4 and 6 weeks, the OAB model group exhibited significant differences in residual volume (RV) and non-voiding contraction frequency. Six-week OAB model group showed much more RV but less voiding efficiency when compared with 6-week sham group or 2-and 4-week OAB model group. Rats that underwent BOO exhibited similarities with the compensated state before four weeks and may have entered decompensated state at six weeks. Studies conducted with 4-week OAB model were appropriate. In part two of the experiment, unstable bladder in the OAB model group recovered bladder stability after SQW treatment, accompanied by improved bladder hypertrophy, as well as corrected urodynamic parameters. Expression of TRPV1 mRNA and proteins in the bladder was significantly greater in the OAB model group than that in the control group, which subsequently decreased significantly with SQW treatment in BOO-induced rats.SQW can modulate the expression of TRPV1 in accordance with the recovery of bladder function." @default.
• W2184320902 created "2016-06-24" @default.
• W2184320902 creator A5024528227 @default.
• W2184320902 creator A5034172944 @default.
• W2184320902 creator A5038827178 @default.
• W2184320902 creator A5038995187 @default.
• W2184320902 creator A5050886789 @default.
• W2184320902 creator A5055178881 @default.
• W2184320902 creator A5058006838 @default.
• W2184320902 creator A5090917459 @default.
• W2184320902 date "2015-12-01" @default.
• W2184320902 modified "2023-10-11" @default.
• W2184320902 title "Effect of the Chinese traditional prescription Suo Quan Wan on TRPV1 expression in the bladder of rats with bladder outlet obstruction" @default.
• W2184320902 cites W1486254512 @default.
• W2184320902 cites W1800213874 @default.
• W2184320902 cites W1967312126 @default.
• W2184320902 cites W1971566600 @default.
• W2184320902 cites W1975401679 @default.
• W2184320902 cites W1988375390 @default.
• W2184320902 cites W1993205491 @default.
• W2184320902 cites W2005096011 @default.
• W2184320902 cites W2013278548 @default.
• W2184320902 cites W2013432695 @default.
• W2184320902 cites W2014026905 @default.
• W2184320902 cites W2017488857 @default.
• W2184320902 cites W2031232505 @default.
• W2184320902 cites W2032546889 @default.
• W2184320902 cites W2051602091 @default.
• W2184320902 cites W2062234342 @default.
• W2184320902 cites W2071320507 @default.
• W2184320902 cites W2076818171 @default.
• W2184320902 cites W2081996521 @default.
• W2184320902 cites W2083126322 @default.
• W2184320902 cites W2094323845 @default.
• W2184320902 cites W2098973758 @default.
• W2184320902 cites W2108847543 @default.
• W2184320902 cites W2122529999 @default.
• W2184320902 cites W2138665941 @default.
• W2184320902 cites W2335543501 @default.
• W2184320902 cites W2383730439 @default.
• W2184320902 cites W2399025443 @default.
• W2184320902 cites W2414247275 @default.
• W2184320902 cites W2419500708 @default.
• W2184320902 cites W2468617382 @default.
• W2184320902 cites W1499776880 @default.
• W2184320902 doi "https://doi.org/10.1186/s12906-015-0898-7" @default.
• W2184320902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4666052" @default.
• W2184320902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26627190" @default.
• W2184320902 hasPublicationYear "2015" @default.
• W2184320902 type Work @default.
• W2184320902 sameAs 2184320902 @default.
• W2184320902 citedByCount "12" @default.
• W2184320902 countsByYear W21843209022016 @default.
• W2184320902 countsByYear W21843209022017 @default.
• W2184320902 countsByYear W21843209022018 @default.
• W2184320902 countsByYear W21843209022019 @default.
• W2184320902 countsByYear W21843209022020 @default.
• W2184320902 countsByYear W21843209022022 @default.
• W2184320902 countsByYear W21843209022023 @default.
• W2184320902 crossrefType "journal-article" @default.
• W2184320902 hasAuthorship W2184320902A5024528227 @default.
• W2184320902 hasAuthorship W2184320902A5034172944 @default.
• W2184320902 hasAuthorship W2184320902A5038827178 @default.
• W2184320902 hasAuthorship W2184320902A5038995187 @default.
• W2184320902 hasAuthorship W2184320902A5050886789 @default.
• W2184320902 hasAuthorship W2184320902A5055178881 @default.
• W2184320902 hasAuthorship W2184320902A5058006838 @default.
• W2184320902 hasAuthorship W2184320902A5090917459 @default.
• W2184320902 hasBestOaLocation W21843209021 @default.
• W2184320902 hasConcept C104317684 @default.
• W2184320902 hasConcept C121608353 @default.
• W2184320902 hasConcept C126322002 @default.
• W2184320902 hasConcept C126894567 @default.
• W2184320902 hasConcept C142724271 @default.
• W2184320902 hasConcept C155164980 @default.
• W2184320902 hasConcept C160145004 @default.
• W2184320902 hasConcept C170493617 @default.
• W2184320902 hasConcept C185592680 @default.
• W2184320902 hasConcept C188947578 @default.
• W2184320902 hasConcept C204787440 @default.
• W2184320902 hasConcept C2776235491 @default.
• W2184320902 hasConcept C2776415932 @default.
• W2184320902 hasConcept C2778941218 @default.
• W2184320902 hasConcept C2779478474 @default.
• W2184320902 hasConcept C2779522043 @default.
• W2184320902 hasConcept C2779762690 @default.
• W2184320902 hasConcept C2780070792 @default.
• W2184320902 hasConcept C55493867 @default.
• W2184320902 hasConcept C71924100 @default.
• W2184320902 hasConceptScore W2184320902C104317684 @default.
• W2184320902 hasConceptScore W2184320902C121608353 @default.
• W2184320902 hasConceptScore W2184320902C126322002 @default.
• W2184320902 hasConceptScore W2184320902C126894567 @default.
• W2184320902 hasConceptScore W2184320902C142724271 @default.
• W2184320902 hasConceptScore W2184320902C155164980 @default.
• W2184320902 hasConceptScore W2184320902C160145004 @default.
• W2184320902 hasConceptScore W2184320902C170493617 @default.
• W2184320902 hasConceptScore W2184320902C185592680 @default.
• W2184320902 hasConceptScore W2184320902C188947578 @default.
• W2184320902 hasConceptScore W2184320902C204787440 @default.

• next