FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2188544979> ?p ?o ?g. }

• W2188544979 endingPage "316" @default.
• W2188544979 startingPage "307" @default.
• W2188544979 abstract "Polyneuropathies are systemic diseases of the nervous system that affect peripheral motor, sensory and vegetative autonomous nerve fibres. The prevalence is 2.4% in the general population and 8% in those older than 55 years. Although inflammatory polyneuropathies represent only about 10% of all polyneuropathies, they are important since they are potentially treatable. They encompass the Guillain-Barre syndrome (GBS) and its chronic sibling chronic inflammatory demyelinating polyneuropathy (CIDP), the vasculitides of the peripheral nervous system (VAS) and polyneuropathies that are associated with autoantibodies, e.g. in the context of a paraproteinaemia. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired immune-mediated neuropathy that causes significant neurological morbidity. Despite the resemblance to the Guillain-Barre syndrome and the observation that immunosuppressive therapies can lead to a clinical improvement the pathogenesis of CIDP is poorly understood. Since CIDP responds to plasmapheresis and intravenous immunoglobulins (IVIG), humoral mechanisms seem to be involved. But so far autoantibodies against various proteins like P0, glycoproteins and glycolipid components such as GM1, LM1, chondroitin sulfate C have only been found in a minority of patients. Most of the mononuclear inflammatory cells in nerve biopsies are macrophages and activated T-lymphocytes. But until now no specific target in human nerves for the T-cell attack could be identified. An interesting aspect is how T cells cross the blood-nerve barrier. We could show that nerve biopsies of patients with CIDP, systemic and non-systemic vasculitis expressed increased levels of the matrix metalloproteinases MMP-9 and MMP-2. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteinases that are effectors of the extracellular matrix remodelling. This may indicate that MMP-9 derives essentially from blood-derived immune cells where it functions as an effector molecule of extravasation and early interstitial infiltration as common pathogenetic mechanisms of inflammatory neuropathies. DNA microarray analysis is a powerful tool for simultaneous analysis and comparison of gene products expressed in normal and diseased tissues. We have undertaken gene expression analysis to identify differentially expressed genes in nerve biopsy samples of CIDP patients and compared the results to nerve biopsies of normal nerve and of vasculitic neuropathy. Of special interest were (1) tachykinin precursor 1, which may be involved in pain mediation; (2) stearoyl-CoA desaturase, which may be a marker for remyelination and (3) the allograft inflammatory factor-1, a modulator of immune response during macrophage activation and marker of blood-vessel damage. Another important aspect of dysimmune polyneuropathies is therapy. The polyneuropathy associated with antibodies to myelin-associated glycoprotein (anti-MAG) is a chronic symmetric sensorimotor demyelinating neuropathy caused by monoclonal IgM against myelin-associated glycoprotein in the context of an IgM paraproteinaemia. Rituximab is a chimeric monoclonal antibody that specifically eliminates normal and malignant B-lymphocytes and B-cell precursors. It is approved to treat B-cell lymphoma in haematology. Rituximab prevents the formation of new antibody-secreting cells and reduces titres of antibodies. We treated in a phase-II, 12-month pilot study 9 patients with anti-MAG neuropathy. There was clinical improvement in 6 of the 9 patients, and 7 had improved nerve conduction studies by at least 10%. These findings were accompanied by laboratory evidence of reduction of B cells, anti-MAG antibodies and total IgM. IgM levels fell to a median of 58% and anti-MAG antibody titres fell to a median of 38% of the initial values one year after treatment." @default.
• W2188544979 created "2016-06-24" @default.
• W2188544979 creator A5016622741 @default.
• W2188544979 date "2006-10-04" @default.
• W2188544979 modified "2023-09-27" @default.
• W2188544979 title "Dysimmune polyneuropathies - new diagnostic and therapeutic insights" @default.
• W2188544979 cites W108555030 @default.
• W2188544979 cites W1553036924 @default.
• W2188544979 cites W1635709196 @default.
• W2188544979 cites W167749285 @default.
• W2188544979 cites W1844711036 @default.
• W2188544979 cites W1968168664 @default.
• W2188544979 cites W1971533561 @default.
• W2188544979 cites W1972773405 @default.
• W2188544979 cites W1975011653 @default.
• W2188544979 cites W1981635387 @default.
• W2188544979 cites W1984786335 @default.
• W2188544979 cites W1986245753 @default.
• W2188544979 cites W1988580787 @default.
• W2188544979 cites W1991497093 @default.
• W2188544979 cites W1993771575 @default.
• W2188544979 cites W1994325619 @default.
• W2188544979 cites W1994623742 @default.
• W2188544979 cites W1997534233 @default.
• W2188544979 cites W1999857229 @default.
• W2188544979 cites W2001197230 @default.
• W2188544979 cites W2001262287 @default.
• W2188544979 cites W2001314174 @default.
• W2188544979 cites W2002434755 @default.
• W2188544979 cites W2006849116 @default.
• W2188544979 cites W2007587185 @default.
• W2188544979 cites W2008969093 @default.
• W2188544979 cites W2009498278 @default.
• W2188544979 cites W2011011837 @default.
• W2188544979 cites W2011257132 @default.
• W2188544979 cites W2012878989 @default.
• W2188544979 cites W2013153064 @default.
• W2188544979 cites W2013377378 @default.
• W2188544979 cites W2014498702 @default.
• W2188544979 cites W2016295391 @default.
• W2188544979 cites W2017081218 @default.
• W2188544979 cites W2018288800 @default.
• W2188544979 cites W2022258023 @default.
• W2188544979 cites W2025118259 @default.
• W2188544979 cites W2027587514 @default.
• W2188544979 cites W2030477156 @default.
• W2188544979 cites W2032743208 @default.
• W2188544979 cites W2038602330 @default.
• W2188544979 cites W2040698632 @default.
• W2188544979 cites W2044047233 @default.
• W2188544979 cites W2049106876 @default.
• W2188544979 cites W2050399061 @default.
• W2188544979 cites W2052613838 @default.
• W2188544979 cites W2053304787 @default.
• W2188544979 cites W2054164739 @default.
• W2188544979 cites W2066524898 @default.
• W2188544979 cites W2066993288 @default.
• W2188544979 cites W2075567629 @default.
• W2188544979 cites W2076906139 @default.
• W2188544979 cites W2079241115 @default.
• W2188544979 cites W2084411352 @default.
• W2188544979 cites W2085425556 @default.
• W2188544979 cites W2086723078 @default.
• W2188544979 cites W2087939951 @default.
• W2188544979 cites W2088679583 @default.
• W2188544979 cites W2089719399 @default.
• W2188544979 cites W2089917415 @default.
• W2188544979 cites W2090913800 @default.
• W2188544979 cites W2093185380 @default.
• W2188544979 cites W2093476884 @default.
• W2188544979 cites W2094613397 @default.
• W2188544979 cites W2095338613 @default.
• W2188544979 cites W2096755516 @default.
• W2188544979 cites W2101697605 @default.
• W2188544979 cites W2102884576 @default.
• W2188544979 cites W2105584327 @default.
• W2188544979 cites W2106134409 @default.
• W2188544979 cites W2111041558 @default.
• W2188544979 cites W2118832722 @default.
• W2188544979 cites W2119103129 @default.
• W2188544979 cites W2122830677 @default.
• W2188544979 cites W2124330386 @default.
• W2188544979 cites W2132744454 @default.
• W2188544979 cites W2134208817 @default.
• W2188544979 cites W2138403718 @default.
• W2188544979 cites W2144441170 @default.
• W2188544979 cites W2147466128 @default.
• W2188544979 cites W2147467901 @default.
• W2188544979 cites W2147751818 @default.
• W2188544979 cites W2148673523 @default.
• W2188544979 cites W2149241174 @default.
• W2188544979 cites W2151395109 @default.
• W2188544979 cites W2160683521 @default.
• W2188544979 cites W2166916539 @default.
• W2188544979 cites W31311722 @default.
• W2188544979 doi "https://doi.org/10.4414/sanp.2006.01774" @default.
• W2188544979 hasPublicationYear "2006" @default.
• W2188544979 type Work @default.

• next