FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2208290061> ?p ?o ?g. }

• W2208290061 endingPage "317" @default.
• W2208290061 startingPage "305" @default.
• W2208290061 abstract "Septic kidney injury is one of the most common complications in critically ill patients with a high risk of developing chronic kidney disease (CKD). Emerging data indicate that mammalian target of rapamyci (mTOR) signaling plays a major role in septic inflammation by regulating the immune response of macrophage. This study was designed to evaluate the role of mTOR signaling in kidney macrophages during endotoxemia-induced chronic kidney injury and subsequent fibrogenesis.Male C57BL/6 mice were used for all animal studies (n=9 for each group). Lipopolysaccharide (LPS) was injected intraperitoneally (1 mg/kg) every 2 days to induce persistent endotoxemia. Rapamycin (1 mg/kg·day) was administered to a subgroup of mice 1 day prior to LPS treatment and continued to termination of the experiment. In ex-vivo experiment, RAW264.7 cells were cultured and treated with LPS (2 µg/ml) for 48 h while a subgroup of cells were incubated in the presence of rapamycin (50 nmol) for 2 h.Continuous administration of LPS resulted in progressive macrophage infiltration, tubular injury and collagen deposition in mice kidneys. Rapamycin markedly ameliorated LPS-induced kidney pathological changes. Expression of pS6K was rarely observed in normal kidney macrophages, but significantly increased with time by LPS treatment. In ex-vivo study, LPS induced prominent production of IL-1β and MCP-1 in cultured RAW264.7 cells, which was significantly suppressed by rapamycin.Taken together, our findings show that endotoxemia results in activation of mTOR signaling in macrophages, leading to progressive kidney inflammatory injuries and subsequent fibrosis. Our study may reveal a mechanism involved in the development of sepsis-associated CKD and kidney fibrosis." @default.
• W2208290061 created "2016-06-24" @default.
• W2208290061 creator A5004491347 @default.
• W2208290061 creator A5017164999 @default.
• W2208290061 creator A5018073672 @default.
• W2208290061 creator A5027470451 @default.
• W2208290061 creator A5042277520 @default.
• W2208290061 creator A5047729392 @default.
• W2208290061 creator A5050155862 @default.
• W2208290061 creator A5056137294 @default.
• W2208290061 creator A5057287134 @default.
• W2208290061 date "2015-01-01" @default.
• W2208290061 modified "2023-10-12" @default.
• W2208290061 title "Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages" @default.
• W2208290061 cites W1864661279 @default.
• W2208290061 cites W1970377223 @default.
• W2208290061 cites W1973174356 @default.
• W2208290061 cites W1987234463 @default.
• W2208290061 cites W1990817996 @default.
• W2208290061 cites W1994455716 @default.
• W2208290061 cites W1995154395 @default.
• W2208290061 cites W1999807547 @default.
• W2208290061 cites W2002690587 @default.
• W2208290061 cites W2003108702 @default.
• W2208290061 cites W2012371191 @default.
• W2208290061 cites W2018969070 @default.
• W2208290061 cites W2019442978 @default.
• W2208290061 cites W2021648310 @default.
• W2208290061 cites W2021690806 @default.
• W2208290061 cites W2025257765 @default.
• W2208290061 cites W2025536703 @default.
• W2208290061 cites W2032368204 @default.
• W2208290061 cites W2038350755 @default.
• W2208290061 cites W2042767581 @default.
• W2208290061 cites W2043310310 @default.
• W2208290061 cites W2054897365 @default.
• W2208290061 cites W2062110054 @default.
• W2208290061 cites W2063974022 @default.
• W2208290061 cites W2065262979 @default.
• W2208290061 cites W2065786649 @default.
• W2208290061 cites W2066697766 @default.
• W2208290061 cites W2072750017 @default.
• W2208290061 cites W2076062022 @default.
• W2208290061 cites W2079079821 @default.
• W2208290061 cites W2082694626 @default.
• W2208290061 cites W2092075198 @default.
• W2208290061 cites W2109335217 @default.
• W2208290061 cites W2110343366 @default.
• W2208290061 cites W2110720586 @default.
• W2208290061 cites W2116929999 @default.
• W2208290061 cites W2117299485 @default.
• W2208290061 cites W2141541010 @default.
• W2208290061 cites W2164655249 @default.
• W2208290061 cites W2164819474 @default.
• W2208290061 cites W2165511737 @default.
• W2208290061 cites W2165909284 @default.
• W2208290061 cites W2170783508 @default.
• W2208290061 doi "https://doi.org/10.1159/000441506" @default.
• W2208290061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26517816" @default.
• W2208290061 hasPublicationYear "2015" @default.
• W2208290061 type Work @default.
• W2208290061 sameAs 2208290061 @default.
• W2208290061 citedByCount "39" @default.
• W2208290061 countsByYear W22082900612016 @default.
• W2208290061 countsByYear W22082900612017 @default.
• W2208290061 countsByYear W22082900612018 @default.
• W2208290061 countsByYear W22082900612019 @default.
• W2208290061 countsByYear W22082900612020 @default.
• W2208290061 countsByYear W22082900612021 @default.
• W2208290061 countsByYear W22082900612022 @default.
• W2208290061 countsByYear W22082900612023 @default.
• W2208290061 crossrefType "journal-article" @default.
• W2208290061 hasAuthorship W2208290061A5004491347 @default.
• W2208290061 hasAuthorship W2208290061A5017164999 @default.
• W2208290061 hasAuthorship W2208290061A5018073672 @default.
• W2208290061 hasAuthorship W2208290061A5027470451 @default.
• W2208290061 hasAuthorship W2208290061A5042277520 @default.
• W2208290061 hasAuthorship W2208290061A5047729392 @default.
• W2208290061 hasAuthorship W2208290061A5050155862 @default.
• W2208290061 hasAuthorship W2208290061A5056137294 @default.
• W2208290061 hasAuthorship W2208290061A5057287134 @default.
• W2208290061 hasConcept C126322002 @default.
• W2208290061 hasConcept C134018914 @default.
• W2208290061 hasConcept C150903083 @default.
• W2208290061 hasConcept C202751555 @default.
• W2208290061 hasConcept C203014093 @default.
• W2208290061 hasConcept C207001950 @default.
• W2208290061 hasConcept C26291073 @default.
• W2208290061 hasConcept C2776914184 @default.
• W2208290061 hasConcept C2778653478 @default.
• W2208290061 hasConcept C2778754761 @default.
• W2208290061 hasConcept C2779244956 @default.
• W2208290061 hasConcept C2780091579 @default.
• W2208290061 hasConcept C2780472472 @default.
• W2208290061 hasConcept C2780559512 @default.
• W2208290061 hasConcept C55493867 @default.
• W2208290061 hasConcept C62478195 @default.
• W2208290061 hasConcept C71924100 @default.

• next