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- W2214235041 abstract "Walther, Christian and Klaus E. Zittlau. Resting membrane properties of locust muscle and their modulation. II. Actions of the biogenic amine octopamine. J. Neurophysiol. 80: 785–797, 1998. Ionic currents in the resting membrane of locust jumping muscle and their modulation by the biogenic amine octopamine were investigated using the two-electrode voltage clamp. A Cl − conductance, G Cl,H , which slowly activates on hyperpolarization, can be induced by raising the intracellular Cl − concentration via diffusion of Cl − ions from the recording electrode. The instantaneous I-V characteristic of the current, I Cl,H , is linear and reverses at the same potential as the γ-aminobutyric acid (GABA)-mediated Cl − current. Elevation of [Cl − ] i increases the maximal steady state G Cl,H ( G max ) and shifts the activation curve of G Cl,H to more positive potentials. Octopamine enhances G Cl,H , mainly by increasing G max . Octopamine also lowers the resting K + conductance ( G K,r ). It reduces a hyperpolarization-activated component ( G K,H ) of G K,r , mainly by decreasing G max . Octopamine also transiently stimulates the Na + /K + pump although this effect was not always seen. The effects of octopamine on the Cl − and K + conductances are mimicked by membrane permeant cyclic nucleotides. The modulation of G K,r , but not that of G Cl,H , seems to be mediated by protein kinase A (PKA). PKA seems to be constitutively activated as indicated by the pronounced increase in G K,r induced by a PKA inhibitor, H89. The properties of G Cl,H and related Cl − conductances in invertebrate and vertebrate neurons are compared. G Cl,H probably supports efflux of Cl − ions accumulating in the fibers during synaptic inhibition. Octopamine's multiple modulation at the level of the muscle cell membrane, in conjunction with previously established effects on synaptic transmission and excitation-contraction coupling, are suited to support strong and rapid muscle contractions." @default.
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- W2214235041 date "1998-08-01" @default.
- W2214235041 modified "2023-10-11" @default.
- W2214235041 title "Resting Membrane Properties of Locust Muscle and Their Modulation II. Actions of the Biogenic Amine Octopamine" @default.
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- W2214235041 doi "https://doi.org/10.1152/jn.1998.80.2.785" @default.
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