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- W2259504741 abstract "Abstract There has been a re-appraisal of the role of cell-mediated immunity in protection against malaria. We have developed a vaccine strategy using chemical attenuation of infected red cells to induce protective cellular immunity. Our focus has been on attenuation using a class of chemicals typified by centanamycin, which binds in AT-rich regions of the parasite genome. Chemically attenuated parasites (CAPs) do not grow in immunodeficient mice. We observe that low doses of Plasmodium chabaudi ring stage CAPs induce profound protection against different strains and species of Plasmodium. CAPs prepared using other species of Plasmodium are also effective. CAPs are rapidly removed from the peripheral blood following vaccination and are taken up by dendritic cells and macrophages in the spleen and liver. Vaccination does not induce detectable antibodies but protection is T-cell dependent. Following vaccination there is a rapid increase within the blood of activated CD4+ T cells (defined as CD49d+ CD11a+). Transfused ovalbumin-specific transgenic OTII cells are not activated following vaccination. This novel approach is now being applied to P. falciparum where we plan to vaccinate humans with low doses of P. falciparum CAP, determine their immune responses and then challenge vaccinees with viable parasite-infected human red cells to determine vaccine efficacy." @default.
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- W2259504741 date "2013-05-01" @default.
- W2259504741 modified "2023-09-23" @default.
- W2259504741 title "Exposure to low doses of chemically attenuated blood stage malaria parasites rapidly activates CD4+ T cells and induces strain and species transcending immunity (P4477)" @default.
- W2259504741 doi "https://doi.org/10.4049/jimmunol.190.supp.179.1" @default.
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