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- W2260848071 abstract "As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a prominent role in regulation of cardiovascular function. GPCRs are effectively “turned off” by GPCR kinases (GRKs) in a process known as “desensitization”. GRKs 2 and 5 are highly expressed in the heart, and known to be upregulated in HF. Over the last 20 years, the role of GRK2 in HF has been widely studied. However, until recently, the role of GRK5 in cardiac pathophysiology had yet to be elucidated. In the present review, we will focus on GRK5's role in the myocardium in normal physiology, and its apparent critical role in the progression of HF. Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in HF." @default.
- W2260848071 created "2016-06-24" @default.
- W2260848071 creator A5027300987 @default.
- W2260848071 creator A5075648082 @default.
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- W2260848071 date "2016-03-01" @default.
- W2260848071 modified "2023-09-24" @default.
- W2260848071 title "“Canonical and non-canonical actions of GRK5 in the heart”" @default.
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- W2260848071 doi "https://doi.org/10.1016/j.yjmcc.2016.01.027" @default.
- W2260848071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4789097" @default.
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- W2260848071 hasPublicationYear "2016" @default.
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