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- W2260928345 abstract "Faithful segregation of chromosomes in mammalian cells requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying cyclin-dependent kinase 1 (CDK1) activation, which triggers mitotic entry, have been extensively studied, the regulatory mechanisms that couple CDK1-cyclin B activity to chromosome stability are not well understood. Here, we identified a signaling axis in which Aurora B activity is modulated by CDK1-cyclin B via the acetyltransferase TIP60 in human cell division. CDK1-cyclin B phosphorylates Ser90 of TIP60, which elicits TIP60-dependent acetylation of Aurora B and promotes accurate chromosome segregation in mitosis. Mechanistically, TIP60 acetylation of Aurora B at Lys215 protects Aurora B's activation loop from dephosphorylation by the phosphatase PP2A to ensure a robust, error-free metaphase-anaphase transition. These findings delineate a conserved signaling cascade that integrates protein phosphorylation and acetylation with cell cycle progression for maintenance of genomic stability." @default.
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- W2260928345 date "2016-02-01" @default.
- W2260928345 modified "2023-10-01" @default.
- W2260928345 title "Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation" @default.
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- W2260928345 doi "https://doi.org/10.1038/nchembio.2017" @default.
- W2260928345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4798883" @default.
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