FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277881506> ?p ?o ?g. }

• W2277881506 endingPage "1662" @default.
• W2277881506 startingPage "1651" @default.
• W2277881506 abstract "Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy without efficient chemotherapeutic agents for it. In our current study, we demonstrated the cytotoxicity effects of a newly patented compound temozolomide-perillyl alcohol (TMZ-POH) on NPC in vitro and in vivo, and the possible mechanisms involved. Human NPC cell lines CNE1, CNE2, HNE2, and SUME-α were treated with control (DMSO), TMZ, POH, TMZ plus POH, and TMZ-POH. Our data indicated that TMZ-POH could inhibit NPC cell proliferation, cause G2/M arrest and DNA damage. TMZ-POH triggered apoptosis in NPC cells via significant activation of caspase-3 and poly(ADP-ribose) polymerase (PARP). Importantly, TMZ-POH-induced cell death was found to be associated with (i) the loss of inner mitochondrial membrane potential (ΔΨm) and release of mitochondrial Cytochrome c, (ii) the increase in ROS generation, and (iii) the activation of stress-activated protein kinases (SAPK)/c-Jun N-terminal kinases (JNK) signaling pathway. The generation of ROS in response to TMZ-POH seems to play a crucial role in the cell death process since the blockage of ROS production using the antioxidant N-acetyl-L-cysteine or catalase reversed the TMZ-POH-induced JNK activation, DNA damage, and cancer cell apoptosis. These results provide the rationale for further research and preclinical investigation of the antitumor effect of TMZ-POH against human NPC." @default.
• W2277881506 created "2016-06-24" @default.
• W2277881506 creator A5008178802 @default.
• W2277881506 creator A5009362044 @default.
• W2277881506 creator A5021838404 @default.
• W2277881506 creator A5032045457 @default.
• W2277881506 creator A5033700028 @default.
• W2277881506 creator A5034571571 @default.
• W2277881506 creator A5060622857 @default.
• W2277881506 creator A5085594231 @default.
• W2277881506 creator A5090702667 @default.
• W2277881506 date "2015-11-27" @default.
• W2277881506 modified "2023-10-16" @default.
• W2277881506 title "Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation" @default.
• W2277881506 cites W1550146738 @default.
• W2277881506 cites W1550247880 @default.
• W2277881506 cites W1752089945 @default.
• W2277881506 cites W1826547551 @default.
• W2277881506 cites W1860682280 @default.
• W2277881506 cites W1967630574 @default.
• W2277881506 cites W1967637796 @default.
• W2277881506 cites W1971344938 @default.
• W2277881506 cites W1971427890 @default.
• W2277881506 cites W1971615535 @default.
• W2277881506 cites W1973206036 @default.
• W2277881506 cites W1976535263 @default.
• W2277881506 cites W1984112998 @default.
• W2277881506 cites W1996338823 @default.
• W2277881506 cites W2024468216 @default.
• W2277881506 cites W2027630134 @default.
• W2277881506 cites W2036515905 @default.
• W2277881506 cites W2044458543 @default.
• W2277881506 cites W2051061475 @default.
• W2277881506 cites W2052756413 @default.
• W2277881506 cites W2056627178 @default.
• W2277881506 cites W2060917950 @default.
• W2277881506 cites W2062219923 @default.
• W2277881506 cites W2068288481 @default.
• W2277881506 cites W2077197422 @default.
• W2277881506 cites W2079614925 @default.
• W2277881506 cites W2089473708 @default.
• W2277881506 cites W2092032912 @default.
• W2277881506 cites W2094144162 @default.
• W2277881506 cites W2096287682 @default.
• W2277881506 cites W2100941957 @default.
• W2277881506 cites W2105360891 @default.
• W2277881506 cites W2112849045 @default.
• W2277881506 cites W2113999599 @default.
• W2277881506 cites W2117581777 @default.
• W2277881506 cites W2132028219 @default.
• W2277881506 cites W2143272637 @default.
• W2277881506 cites W2154932244 @default.
• W2277881506 cites W2158649478 @default.
• W2277881506 cites W2330429470 @default.
• W2277881506 cites W4211070369 @default.
• W2277881506 doi "https://doi.org/10.18632/oncotarget.6410" @default.
• W2277881506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4811487" @default.
• W2277881506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26625208" @default.
• W2277881506 hasPublicationYear "2015" @default.
• W2277881506 type Work @default.
• W2277881506 sameAs 2277881506 @default.
• W2277881506 citedByCount "9" @default.
• W2277881506 countsByYear W22778815062017 @default.
• W2277881506 countsByYear W22778815062018 @default.
• W2277881506 countsByYear W22778815062019 @default.
• W2277881506 countsByYear W22778815062020 @default.
• W2277881506 countsByYear W22778815062022 @default.
• W2277881506 countsByYear W22778815062023 @default.
• W2277881506 crossrefType "journal-article" @default.
• W2277881506 hasAuthorship W2277881506A5008178802 @default.
• W2277881506 hasAuthorship W2277881506A5009362044 @default.
• W2277881506 hasAuthorship W2277881506A5021838404 @default.
• W2277881506 hasAuthorship W2277881506A5032045457 @default.
• W2277881506 hasAuthorship W2277881506A5033700028 @default.
• W2277881506 hasAuthorship W2277881506A5034571571 @default.
• W2277881506 hasAuthorship W2277881506A5060622857 @default.
• W2277881506 hasAuthorship W2277881506A5085594231 @default.
• W2277881506 hasAuthorship W2277881506A5090702667 @default.
• W2277881506 hasBestOaLocation W22778815061 @default.
• W2277881506 hasConcept C126322002 @default.
• W2277881506 hasConcept C143425029 @default.
• W2277881506 hasConcept C182979987 @default.
• W2277881506 hasConcept C184235292 @default.
• W2277881506 hasConcept C185592680 @default.
• W2277881506 hasConcept C190283241 @default.
• W2277881506 hasConcept C2776151105 @default.
• W2277881506 hasConcept C2778997737 @default.
• W2277881506 hasConcept C29311851 @default.
• W2277881506 hasConcept C31573885 @default.
• W2277881506 hasConcept C48349386 @default.
• W2277881506 hasConcept C502942594 @default.
• W2277881506 hasConcept C509974204 @default.
• W2277881506 hasConcept C552990157 @default.
• W2277881506 hasConcept C55493867 @default.
• W2277881506 hasConcept C71924100 @default.
• W2277881506 hasConcept C82381507 @default.
• W2277881506 hasConcept C86803240 @default.
• W2277881506 hasConcept C95444343 @default.

• next