FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279967268> ?p ?o ?g. }

• W2279967268 endingPage "93" @default.
• W2279967268 startingPage "85" @default.
• W2279967268 abstract "Studies demonstrated that perfluorooctane sulfonate (PFOS) tends to accumulate in the liver and is capable to cause hepatomegaly. In the present study, we investigated the roles of miR-155 in PFOS-induced hepatotoxicity in SD rats and HepG2 cells. Male SD rats were orally administrated with PFOS at 1 or 10mg/kg/day for 28 days while HepG2 cells were treated with 0-50 μM of PFOS for 24h or 50 μM of PFOS for 1, 3, 6, 12 or 24h, respectively. We found that PFOS significantly increased the liver weight and serum alanine transaminase (ALT) and aspartate amino transferase (AST) levels in rats. Morphologically, PFOS caused actin filament remodeling and endothelial permeability changes in the liver. Moreover, PFOS triggered reactive oxygen species (ROS) generation and induced apoptosis in both in vivo and in vitro assays. Immunoblotting data showed that NF-E2-related factor-2 (Nrf2) expression and activation and its target genes were all suppressed by PFOS in the liver and HepG2 cells. However, PFOS significantly increased miR-155 expression. Further studies showed that pretreatment of HepG2 cells with catalase significantly decreased miR-155 expression and substantially increased Nrf2 expression and activation, resulting in reduction of PFOS-induced cytotoxicity and oxidative stress. Taken together, these results indicated that miR-155 plays an important role in the PFOS-induced hepatotoxicity by disrupting Nrf2/ARE signaling pathway." @default.
• W2279967268 created "2016-06-24" @default.
• W2279967268 creator A5006052857 @default.
• W2279967268 creator A5047916176 @default.
• W2279967268 creator A5073053328 @default.
• W2279967268 creator A5081666408 @default.
• W2279967268 creator A5084130934 @default.
• W2279967268 creator A5091488249 @default.
• W2279967268 creator A5091621664 @default.
• W2279967268 date "2016-03-01" @default.
• W2279967268 modified "2023-10-12" @default.
• W2279967268 title "Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway" @default.
• W2279967268 cites W1971448133 @default.
• W2279967268 cites W1971687421 @default.
• W2279967268 cites W1974264164 @default.
• W2279967268 cites W1976393083 @default.
• W2279967268 cites W1976770880 @default.
• W2279967268 cites W1978131498 @default.
• W2279967268 cites W1989427047 @default.
• W2279967268 cites W1998162803 @default.
• W2279967268 cites W2005218097 @default.
• W2279967268 cites W2007867750 @default.
• W2279967268 cites W2014235257 @default.
• W2279967268 cites W2014946489 @default.
• W2279967268 cites W2015186145 @default.
• W2279967268 cites W2017857120 @default.
• W2279967268 cites W2020004405 @default.
• W2279967268 cites W2032164646 @default.
• W2279967268 cites W2039898654 @default.
• W2279967268 cites W2049354575 @default.
• W2279967268 cites W2050483892 @default.
• W2279967268 cites W2055130924 @default.
• W2279967268 cites W2058536680 @default.
• W2279967268 cites W2064617875 @default.
• W2279967268 cites W2065481320 @default.
• W2279967268 cites W2068961255 @default.
• W2279967268 cites W2071584290 @default.
• W2279967268 cites W2072007513 @default.
• W2279967268 cites W2073703119 @default.
• W2279967268 cites W2075414439 @default.
• W2279967268 cites W2075728036 @default.
• W2279967268 cites W2078042539 @default.
• W2279967268 cites W2082208126 @default.
• W2279967268 cites W2087691088 @default.
• W2279967268 cites W2095383695 @default.
• W2279967268 cites W2110151226 @default.
• W2279967268 cites W2115938949 @default.
• W2279967268 cites W2122341467 @default.
• W2279967268 cites W2123206621 @default.
• W2279967268 cites W2124050512 @default.
• W2279967268 cites W2140638808 @default.
• W2279967268 cites W2147924866 @default.
• W2279967268 cites W2147993424 @default.
• W2279967268 cites W2160921325 @default.
• W2279967268 cites W2167567374 @default.
• W2279967268 cites W2169325666 @default.
• W2279967268 cites W2179490415 @default.
• W2279967268 doi "https://doi.org/10.1016/j.taap.2016.01.023" @default.
• W2279967268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26844784" @default.
• W2279967268 hasPublicationYear "2016" @default.
• W2279967268 type Work @default.
• W2279967268 sameAs 2279967268 @default.
• W2279967268 citedByCount "43" @default.
• W2279967268 countsByYear W22799672682016 @default.
• W2279967268 countsByYear W22799672682017 @default.
• W2279967268 countsByYear W22799672682018 @default.
• W2279967268 countsByYear W22799672682019 @default.
• W2279967268 countsByYear W22799672682020 @default.
• W2279967268 countsByYear W22799672682021 @default.
• W2279967268 countsByYear W22799672682022 @default.
• W2279967268 countsByYear W22799672682023 @default.
• W2279967268 crossrefType "journal-article" @default.
• W2279967268 hasAuthorship W2279967268A5006052857 @default.
• W2279967268 hasAuthorship W2279967268A5047916176 @default.
• W2279967268 hasAuthorship W2279967268A5073053328 @default.
• W2279967268 hasAuthorship W2279967268A5081666408 @default.
• W2279967268 hasAuthorship W2279967268A5084130934 @default.
• W2279967268 hasAuthorship W2279967268A5091488249 @default.
• W2279967268 hasAuthorship W2279967268A5091621664 @default.
• W2279967268 hasConcept C126322002 @default.
• W2279967268 hasConcept C134018914 @default.
• W2279967268 hasConcept C150903083 @default.
• W2279967268 hasConcept C160160445 @default.
• W2279967268 hasConcept C178790620 @default.
• W2279967268 hasConcept C181199279 @default.
• W2279967268 hasConcept C185592680 @default.
• W2279967268 hasConcept C190283241 @default.
• W2279967268 hasConcept C207001950 @default.
• W2279967268 hasConcept C2776151105 @default.
• W2279967268 hasConcept C2776637226 @default.
• W2279967268 hasConcept C2778606649 @default.
• W2279967268 hasConcept C2778894819 @default.
• W2279967268 hasConcept C2778979269 @default.
• W2279967268 hasConcept C2779679107 @default.
• W2279967268 hasConcept C2781314072 @default.
• W2279967268 hasConcept C48349386 @default.
• W2279967268 hasConcept C537181965 @default.
• W2279967268 hasConcept C55493867 @default.

• next