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- W2286547534 abstract "1. Rats, dogs and monkeys appeared to show no physiological abnormality when the cholinesterase of the blood and tissues was reduced to a low percentage of its normal activity by di-isopropyl fluorophosphate. The signs associated with further reduction are described. 2. It was found that determinations of serum and red cell cholinesterase inhibition following the administration of di-isopropyl fluorophosphate do not provide accurate estimates of the activity of the enzyme in the tissues, excepting possibly during the period immediately following a single dose. Such measurements can be used advantageously to follow rates of absorption. 3. No deterioration was detected in solutions of di-isopropyl fluorophosphate in peanut oil following autoclaving for one hour or storage at room temperature for one year. 4. The concentration of a peanut oil solution of di-isopropyl fluorophosphate had little effect on its rate of absorption from an intramuscular site in dogs. 5. The effective intramuscular:oral dosage ratio for di-isopropyl fluorophosphate in peanut oil was found to be approximately 1:4 in monkeys and humans." @default.
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- W2286547534 date "1946-08-01" @default.
- W2286547534 modified "2023-09-23" @default.
- W2286547534 title "The relationship between cholinesterase inhibition and the pharmacological action of di-isopropyl fluorophosphate (DFP)." @default.
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