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- W2316367956 abstract "ABSTRACT Objective: Chemotherapy-induced intestinal toxicity is a common adverse effect of cancer treatment. We hypothesized that a milk diet containing bovine colostrum (BC) would reduce intestinal toxicity in doxorubicin-treated piglets. Methods: “Study 1” investigated intestinal parameters 9 days after a single dose of doxorubicin (1 × 75 mg/m 2 ) in piglets fed bovine milk enriched with whey protein (BM). In “study 2,” responses to doxorubicin treatment were investigated in piglets receiving either 7 BC feedings per day (Only-BC, n = 13), 4 BC feedings (High-BC, n = 13), 2 BC feedings (Low-BC, n = 14), or no BC (only BM, n = 13). Results: Doxorubicin treatment induced clinical signs of intestinal toxicity with diarrhea and weight loss, relative to controls ( P < 0.05). White blood cells, hexose absorptive function, plasma citrulline, weights of intestine, colon, and spleen were reduced, whereas gut permeability and plasma C-reactive protein levels were increased (all P < 0.05). Limited or no effects were observed for digestive enzymes, proinflammatory cytokines, or tight-junction proteins in the intestine. Increasing BC supplementation to doxorubicin-treated piglets (study 2) had no consistent effects on plasma C-reactive protein and citrulline levels, intestinal morphology, digestive enzymes, permeability, or proinflammatory cytokines. Only-BC pigs, however, had lower diarrhea severity toward the end of the experiment ( P < 0.05 vs BM) and across the BC groups, intestinal toxicity was reduced ( P < 0.01). Conclusions: Doxorubicin-treated piglets are relevant for studying chemotherapy-induced gut toxicity. Colostrum supplementation had limited effects on doxorubicin-induced toxicity in milk-fed piglets suggesting that colostrum and a bovine milk diet enriched with whey protein provided similar protection of the developing intestine from chemotherapy-induced toxicity." @default.
- W2316367956 created "2016-06-24" @default.
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- W2316367956 date "2016-12-01" @default.
- W2316367956 modified "2023-09-27" @default.
- W2316367956 title "Doxorubicin-Induced Gut Toxicity in Piglets Fed Bovine Milk and Colostrum" @default.
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- W2316367956 doi "https://doi.org/10.1097/mpg.0000000000001205" @default.
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