FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321209095> ?p ?o ?g. }

• W2321209095 endingPage "786" @default.
• W2321209095 startingPage "779" @default.
• W2321209095 abstract "Glioblastomas with a specific mutation in the isocitrate dehydrogenase 1 (IDH1) gene have a better prognosis than gliomas with wild-type IDH1. Here we compare the IDH1 mutational status in 172 contrast-enhancing glioma patients with the invasion profile generated by a patient-specific mathematical model we developed based on MR imaging. We show that IDH1-mutated contrast-enhancing gliomas were relatively more invasive than wild-type IDH1 for all 172 contrast-enhancing gliomas as well as the subset of 158 histologically confirmed glioblastomas. The appearance of this relatively increased, model-predicted invasive profile appears to be determined more by a lower model-predicted net proliferation rate rather than an increased model-predicted dispersal rate of the glioma cells. Receiver operator curve analysis of the model-predicted MRI-based invasion profile revealed an area under the curve of 0.91, indicative of a predictive relationship. The robustness of this relationship was tested by cross-validation analysis of the invasion profile as a predictive metric for IDH1 status. The strong correlation between IDH1 mutation status and the MRI-based invasion profile suggests that use of our tumor growth model may lead to noninvasive clinical detection of IDH1 mutation status and thus lead to better treatment planning, particularly prior to surgical resection, for contrast-enhancing gliomas." @default.
• W2321209095 created "2016-06-24" @default.
• W2321209095 creator A5003774553 @default.
• W2321209095 creator A5005607513 @default.
• W2321209095 creator A5006366010 @default.
• W2321209095 creator A5008147901 @default.
• W2321209095 creator A5011125577 @default.
• W2321209095 creator A5014011778 @default.
• W2321209095 creator A5014909652 @default.
• W2321209095 creator A5024863178 @default.
• W2321209095 creator A5026346370 @default.
• W2321209095 creator A5031987031 @default.
• W2321209095 creator A5046673359 @default.
• W2321209095 creator A5047350835 @default.
• W2321209095 creator A5056561758 @default.
• W2321209095 creator A5060408739 @default.
• W2321209095 creator A5074643952 @default.
• W2321209095 creator A5088252436 @default.
• W2321209095 creator A5091554927 @default.
• W2321209095 date "2014-06-01" @default.
• W2321209095 modified "2023-10-16" @default.
• W2321209095 title "Invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status" @default.
• W2321209095 cites W2003857914 @default.
• W2321209095 cites W2006322120 @default.
• W2321209095 cites W2019438752 @default.
• W2321209095 cites W2024080420 @default.
• W2321209095 cites W2037011508 @default.
• W2321209095 cites W2038722924 @default.
• W2321209095 cites W2040827479 @default.
• W2321209095 cites W2056315075 @default.
• W2321209095 cites W2071948601 @default.
• W2321209095 cites W2084945856 @default.
• W2321209095 cites W2100723895 @default.
• W2321209095 cites W2100901335 @default.
• W2321209095 cites W2105348749 @default.
• W2321209095 cites W2111967308 @default.
• W2321209095 cites W2112130807 @default.
• W2321209095 cites W2118604693 @default.
• W2321209095 cites W2120963683 @default.
• W2321209095 cites W2122510170 @default.
• W2321209095 cites W2126817554 @default.
• W2321209095 cites W2134204340 @default.
• W2321209095 cites W2138509761 @default.
• W2321209095 cites W2139899744 @default.
• W2321209095 cites W2141226754 @default.
• W2321209095 cites W2149363397 @default.
• W2321209095 cites W2164547751 @default.
• W2321209095 cites W2165274879 @default.
• W2321209095 cites W2168784615 @default.
• W2321209095 doi "https://doi.org/10.1093/neuonc/nou027" @default.
• W2321209095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4022227" @default.
• W2321209095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24832620" @default.
• W2321209095 hasPublicationYear "2014" @default.
• W2321209095 type Work @default.
• W2321209095 sameAs 2321209095 @default.
• W2321209095 citedByCount "76" @default.
• W2321209095 countsByYear W23212090952014 @default.
• W2321209095 countsByYear W23212090952015 @default.
• W2321209095 countsByYear W23212090952016 @default.
• W2321209095 countsByYear W23212090952017 @default.
• W2321209095 countsByYear W23212090952018 @default.
• W2321209095 countsByYear W23212090952019 @default.
• W2321209095 countsByYear W23212090952020 @default.
• W2321209095 countsByYear W23212090952021 @default.
• W2321209095 countsByYear W23212090952022 @default.
• W2321209095 countsByYear W23212090952023 @default.
• W2321209095 crossrefType "journal-article" @default.
• W2321209095 hasAuthorship W2321209095A5003774553 @default.
• W2321209095 hasAuthorship W2321209095A5005607513 @default.
• W2321209095 hasAuthorship W2321209095A5006366010 @default.
• W2321209095 hasAuthorship W2321209095A5008147901 @default.
• W2321209095 hasAuthorship W2321209095A5011125577 @default.
• W2321209095 hasAuthorship W2321209095A5014011778 @default.
• W2321209095 hasAuthorship W2321209095A5014909652 @default.
• W2321209095 hasAuthorship W2321209095A5024863178 @default.
• W2321209095 hasAuthorship W2321209095A5026346370 @default.
• W2321209095 hasAuthorship W2321209095A5031987031 @default.
• W2321209095 hasAuthorship W2321209095A5046673359 @default.
• W2321209095 hasAuthorship W2321209095A5047350835 @default.
• W2321209095 hasAuthorship W2321209095A5056561758 @default.
• W2321209095 hasAuthorship W2321209095A5060408739 @default.
• W2321209095 hasAuthorship W2321209095A5074643952 @default.
• W2321209095 hasAuthorship W2321209095A5088252436 @default.
• W2321209095 hasAuthorship W2321209095A5091554927 @default.
• W2321209095 hasBestOaLocation W23212090951 @default.
• W2321209095 hasConcept C104317684 @default.
• W2321209095 hasConcept C127848430 @default.
• W2321209095 hasConcept C142724271 @default.
• W2321209095 hasConcept C143065580 @default.
• W2321209095 hasConcept C143998085 @default.
• W2321209095 hasConcept C181199279 @default.
• W2321209095 hasConcept C207583985 @default.
• W2321209095 hasConcept C2777150147 @default.
• W2321209095 hasConcept C2778227246 @default.
• W2321209095 hasConcept C501734568 @default.
• W2321209095 hasConcept C502942594 @default.
• W2321209095 hasConcept C54355233 @default.
• W2321209095 hasConcept C55493867 @default.

• next