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- W2323529181 abstract "Because lipids had been consistently detected histologically at sites of new calcification, the lipids of epiphyseal cartilage and bone in various stages of mineralization were examined. Lipids were extracted before and after demineraliza- tion and analyzed. Lipid content increased during prolifera- tion and calcification of epiphyseal cartilage. Much less was seen in the adjacent cancellous bone; this corroborates histo- chemical findings. Similar phospholipid compositions were seen in the total lipids of cartilage and bone. Neutral (dipolar) phospholipids accounted for nearly 90% of the total lipid P and were almost completely extracted before demineralization. Serine- and inositol-containing phospholipids and two other, unidentified, acidic lipids could not be effectively extracted from calcify- ing tissues until after demineralization. Since the extraction of the acidic lipids was closely related to the degree of mineraliza- tion, it is possible that they form part of a lipoprotein-mineral complex in the calcifying matrix. Lysophospholipids were detected in all extracts, but pri- marily in those made after decalcification. It is concluded that acidic lipids are mainly responsible for the sudanophilia de- tected histologically at sites of new calcification." @default.
- W2323529181 created "2016-06-24" @default.
- W2323529181 creator A5026947339 @default.
- W2323529181 date "1968-01-01" @default.
- W2323529181 modified "2023-09-25" @default.
- W2323529181 title "Lipids of mineralizing epiphyseal tissues in the bovine fetus" @default.
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- W2323529181 doi "https://doi.org/10.1016/s0022-2275(20)43145-1" @default.
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