Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324431387> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2324431387 abstract "INTRODUCTION & METHODOLOGY.The objective of this review is to identify from the two WHI published randomized HRT trials the BrCa risk or benefit, with a special focus on different impact of E2-alone vs E2+Prog on human breast carcinogenesis (BrCa-genesis).In the 1st trial (JAMA 2002, 2007), healthy women age 50 - 79 were randomized to E2 plus Prog versus placebo (Plac). Reviewed were Hazard ratios (HRs) for all pts and also for those with or without prior Hormone use. Mean follow up was 5.2 years.In the 2nd trial (JAMA 2004, 2006), women with hysterectomy age 50 - 79 were randomized to E2 alone (without Prog) versus Plac. Mean follow up was 7.1 years. Reviewed were all pts, and also subsets with or without prior E2 or Prog; with or without prior history of Benign Breast Disease (PHBrD); and with or without prior history of a 1st degree relative with BrCa (PH1stRelBrCa).RESULTS.CONCLUSION:1. Results from the 1st trial show that concomitant use of E2 with Prog, particularly in women with prior Hormone use, is associated with increased BrCa hazards.2. The results of the 2nd HRT trial indicate that use of HRT with E2 alone is associated with a reduction in BrCa incidence, significant in the majority of women with no prior BrCa risk factors. Also the results show that prior Prog but not prior E2 elevate the risk.3. These data indicate that HRT with E2 alone has a BrCa protective effect, while adding Prog increases the risk.4. These results are also compatible with a dual E2 effect on BrCa-genesis, where exogenous E2 are protective, but endogenous E2 [endE2] are carcinogenic, as shown from decades of anti-end E2 research with Tamoxifen, oophorectomy or Aromatase inhibitors.5. Based on these data we propose that in women with hysterectomy and no prior history of risk factors, the use of HRT with E2 alone as chemoprevention is plausible, and needs urgent verification.* significance, p Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 908." @default.
- W2324431387 created "2016-06-24" @default.
- W2324431387 creator A5023428946 @default.
- W2324431387 creator A5054500022 @default.
- W2324431387 creator A5079123761 @default.
- W2324431387 creator A5090228144 @default.
- W2324431387 date "2009-12-15" @default.
- W2324431387 modified "2023-09-27" @default.
- W2324431387 title "Protective Effect of Estrogen (E2) and Increased Risk of E2 Plus Progestin (Prog) on Breast Cancer (BrCa). The 2009 Review of the Women's Health Initiative (WHI) Hormone Replacement Therapy (HRT) Published Trials." @default.
- W2324431387 doi "https://doi.org/10.1158/0008-5472.sabcs-09-908" @default.
- W2324431387 hasPublicationYear "2009" @default.
- W2324431387 type Work @default.
- W2324431387 sameAs 2324431387 @default.
- W2324431387 citedByCount "0" @default.
- W2324431387 crossrefType "proceedings-article" @default.
- W2324431387 hasAuthorship W2324431387A5023428946 @default.
- W2324431387 hasAuthorship W2324431387A5054500022 @default.
- W2324431387 hasAuthorship W2324431387A5079123761 @default.
- W2324431387 hasAuthorship W2324431387A5090228144 @default.
- W2324431387 hasConcept C121608353 @default.
- W2324431387 hasConcept C126322002 @default.
- W2324431387 hasConcept C143998085 @default.
- W2324431387 hasConcept C168563851 @default.
- W2324431387 hasConcept C207103383 @default.
- W2324431387 hasConcept C2776607906 @default.
- W2324431387 hasConcept C2777164284 @default.
- W2324431387 hasConcept C2779279991 @default.
- W2324431387 hasConcept C2780159708 @default.
- W2324431387 hasConcept C2780275930 @default.
- W2324431387 hasConcept C2780733421 @default.
- W2324431387 hasConcept C29456083 @default.
- W2324431387 hasConcept C3018603563 @default.
- W2324431387 hasConcept C44249647 @default.
- W2324431387 hasConcept C530470458 @default.
- W2324431387 hasConcept C71924100 @default.
- W2324431387 hasConceptScore W2324431387C121608353 @default.
- W2324431387 hasConceptScore W2324431387C126322002 @default.
- W2324431387 hasConceptScore W2324431387C143998085 @default.
- W2324431387 hasConceptScore W2324431387C168563851 @default.
- W2324431387 hasConceptScore W2324431387C207103383 @default.
- W2324431387 hasConceptScore W2324431387C2776607906 @default.
- W2324431387 hasConceptScore W2324431387C2777164284 @default.
- W2324431387 hasConceptScore W2324431387C2779279991 @default.
- W2324431387 hasConceptScore W2324431387C2780159708 @default.
- W2324431387 hasConceptScore W2324431387C2780275930 @default.
- W2324431387 hasConceptScore W2324431387C2780733421 @default.
- W2324431387 hasConceptScore W2324431387C29456083 @default.
- W2324431387 hasConceptScore W2324431387C3018603563 @default.
- W2324431387 hasConceptScore W2324431387C44249647 @default.
- W2324431387 hasConceptScore W2324431387C530470458 @default.
- W2324431387 hasConceptScore W2324431387C71924100 @default.
- W2324431387 hasLocation W23244313871 @default.
- W2324431387 hasOpenAccess W2324431387 @default.
- W2324431387 hasPrimaryLocation W23244313871 @default.
- W2324431387 hasRelatedWork W1970191521 @default.
- W2324431387 hasRelatedWork W2005232022 @default.
- W2324431387 hasRelatedWork W2049077879 @default.
- W2324431387 hasRelatedWork W2052824750 @default.
- W2324431387 hasRelatedWork W2060441344 @default.
- W2324431387 hasRelatedWork W2069908846 @default.
- W2324431387 hasRelatedWork W2074119596 @default.
- W2324431387 hasRelatedWork W2077973333 @default.
- W2324431387 hasRelatedWork W2121476566 @default.
- W2324431387 hasRelatedWork W2137538514 @default.
- W2324431387 hasRelatedWork W2142696583 @default.
- W2324431387 hasRelatedWork W2148120400 @default.
- W2324431387 hasRelatedWork W2333865370 @default.
- W2324431387 hasRelatedWork W2800412330 @default.
- W2324431387 hasRelatedWork W2894672081 @default.
- W2324431387 hasRelatedWork W2935812534 @default.
- W2324431387 hasRelatedWork W2943896988 @default.
- W2324431387 hasRelatedWork W2955696602 @default.
- W2324431387 hasRelatedWork W3013390527 @default.
- W2324431387 hasRelatedWork W3208548481 @default.
- W2324431387 isParatext "false" @default.
- W2324431387 isRetracted "false" @default.
- W2324431387 magId "2324431387" @default.
- W2324431387 workType "article" @default.