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- W2324510110 abstract "T-cell lymphomas expressing the T-cell receptor (TCR) are uncommon, although their frequency may be underestimated. They show a broad clinicopathological spectrum. Besides precursor T-cell lymphoblastic leukemia/ lymphoma, various post-thymic T-cell neoplasms have been recognized. Among these, hepatosplenic T-cell lymphoma constitutes the prototype of T-cell lymphomas expressing the TCR and was listed as a provisional entity in the Revised European-American Lymphoma (REAL) classification. The recognition of this lymphoma subtype was further supported by the demonstration that the neoplasm results from a proliferation of nonactivated cytotoxic T cells and is associated with a recurrent cytogenetic abnormality, the isochromosome 7q. More recently, a few cases of hepatosplenic T-cell lymphoma with similar clinicopathologic features and phenotype have been described that are thought to belong to the same entity, and the term “hepatosplenic T-cell lymphoma” is preferred in the current World Health Organization (WHO) classification. Most nonhepatosplenic T-cell lymphomas occur in skin or in mucosal sites, a location that parallels that of normal T cells. In contrast to hepatosplenic T-cell lymphomas, they show an important clinical and morphological heterogeneity, have an activated cytotoxic phenotype, and are not believed to constitute a single disease entity. Semin Hematol 40:233-243. © 2003 Elsevier Inc. All rights reserved." @default.
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- W2324510110 date "2003-01-01" @default.
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- W2324510110 title "T-Cell Lymphomas" @default.
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