FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333481531> ?p ?o ?g. }

• W2333481531 endingPage "3037" @default.
• W2333481531 startingPage "3029" @default.
• W2333481531 abstract "Human embryonic stem cells (hESCs) can serve as a universal cell source for emerging cell or tissue replacement strategies, but immune rejection of hESC derivatives remains an unsolved problem. Here, we sought to describe the mechanisms of rejection for naïve hESCs and upon HLA class I (HLA I) knockdown (hESCKD). hESCs were HLA I-positive but negative for HLA II and co-stimulatory molecules. Transplantation of naïve hESC into immunocompetent Balb/c mice induced substantial T helper cell 1 and 2 (Th1 and Th2) responses with rapid cell death, but hESCs survived in immunodeficient SCID-beige recipients. Histology revealed mainly macrophages and T cells, but only scattered natural killer (NK) cells. A surge of hESC-specific antibodies against hESC class I, but not class II antigens, was observed. Using HLA I RNA interference and intrabody technology, HLA I surface expression of hESCKD was 88%–99% reduced. T cell activation after hESCKD transplantation into Balb/c was significantly diminished, antibody production was substantially alleviated, the levels of graft-infiltrating immune cells were reduced and the survival of hESCKD was prolonged. Because of their very low expression of stimulatory NK ligands, NK-susceptibility of naïve hESCs and hESCKD was negligible. Thus, HLA I recognition by T cells seems to be the primary mechanism of hESC recognition, and T cells, macrophages and hESC-specific antibodies participate in hESC killing." @default.
• W2333481531 created "2016-06-24" @default.
• W2333481531 creator A5012668274 @default.
• W2333481531 creator A5020201354 @default.
• W2333481531 creator A5021487648 @default.
• W2333481531 creator A5040644146 @default.
• W2333481531 creator A5046335478 @default.
• W2333481531 creator A5049060150 @default.
• W2333481531 creator A5050688887 @default.
• W2333481531 creator A5052658460 @default.
• W2333481531 creator A5054247350 @default.
• W2333481531 creator A5057231025 @default.
• W2333481531 creator A5058198453 @default.
• W2333481531 creator A5066113444 @default.
• W2333481531 creator A5076167190 @default.
• W2333481531 creator A5088003457 @default.
• W2333481531 date "2011-09-01" @default.
• W2333481531 modified "2023-10-14" @default.
• W2333481531 title "Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells" @default.
• W2333481531 cites W1504290562 @default.
• W2333481531 cites W1661600713 @default.
• W2333481531 cites W1755470392 @default.
• W2333481531 cites W1953821950 @default.
• W2333481531 cites W1966127544 @default.
• W2333481531 cites W1968238223 @default.
• W2333481531 cites W1972104056 @default.
• W2333481531 cites W1974609577 @default.
• W2333481531 cites W1986100684 @default.
• W2333481531 cites W1987980051 @default.
• W2333481531 cites W1988266325 @default.
• W2333481531 cites W1989466512 @default.
• W2333481531 cites W1992273666 @default.
• W2333481531 cites W2002372399 @default.
• W2333481531 cites W2003593107 @default.
• W2333481531 cites W2005972147 @default.
• W2333481531 cites W2006712783 @default.
• W2333481531 cites W2010177021 @default.
• W2333481531 cites W2017043267 @default.
• W2333481531 cites W2020236947 @default.
• W2333481531 cites W2026638749 @default.
• W2333481531 cites W2027295876 @default.
• W2333481531 cites W2038789463 @default.
• W2333481531 cites W2039715282 @default.
• W2333481531 cites W2040646120 @default.
• W2333481531 cites W2045626197 @default.
• W2333481531 cites W2046079641 @default.
• W2333481531 cites W2048722591 @default.
• W2333481531 cites W2052215223 @default.
• W2333481531 cites W2055287357 @default.
• W2333481531 cites W2056645320 @default.
• W2333481531 cites W2058256440 @default.
• W2333481531 cites W2059354338 @default.
• W2333481531 cites W2065860650 @default.
• W2333481531 cites W2077261973 @default.
• W2333481531 cites W2077670728 @default.
• W2333481531 cites W2078916311 @default.
• W2333481531 cites W2086546881 @default.
• W2333481531 cites W2087419032 @default.
• W2333481531 cites W2088108906 @default.
• W2333481531 cites W2089300804 @default.
• W2333481531 cites W2089488963 @default.
• W2333481531 cites W2094995166 @default.
• W2333481531 cites W2100491180 @default.
• W2333481531 cites W2103208662 @default.
• W2333481531 cites W2111068169 @default.
• W2333481531 cites W2115096499 @default.
• W2333481531 cites W2116826060 @default.
• W2333481531 cites W2124812176 @default.
• W2333481531 cites W2127905517 @default.
• W2333481531 cites W2128923693 @default.
• W2333481531 cites W2133014598 @default.
• W2333481531 cites W2136447541 @default.
• W2333481531 cites W2138445309 @default.
• W2333481531 cites W2151517892 @default.
• W2333481531 cites W2158470819 @default.
• W2333481531 cites W2160603504 @default.
• W2333481531 cites W2169859308 @default.
• W2333481531 cites W2170725518 @default.
• W2333481531 cites W2325262295 @default.
• W2333481531 doi "https://doi.org/10.1242/jcs.087718" @default.
• W2333481531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21878509" @default.
• W2333481531 hasPublicationYear "2011" @default.
• W2333481531 type Work @default.
• W2333481531 sameAs 2333481531 @default.
• W2333481531 citedByCount "35" @default.
• W2333481531 countsByYear W23334815312012 @default.
• W2333481531 countsByYear W23334815312013 @default.
• W2333481531 countsByYear W23334815312015 @default.
• W2333481531 countsByYear W23334815312016 @default.
• W2333481531 countsByYear W23334815312017 @default.
• W2333481531 countsByYear W23334815312018 @default.
• W2333481531 countsByYear W23334815312019 @default.
• W2333481531 countsByYear W23334815312020 @default.
• W2333481531 countsByYear W23334815312021 @default.
• W2333481531 countsByYear W23334815312023 @default.
• W2333481531 crossrefType "journal-article" @default.
• W2333481531 hasAuthorship W2333481531A5012668274 @default.
• W2333481531 hasAuthorship W2333481531A5020201354 @default.

• next