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- W2334184609 abstract "Objective: To investigate the relationship between juxtacortical lesion volume and cognitive performance in early onset relapsing remitting multiple sclerosis (RRMS) patients from Buenos Aires, Argentina. Design/Methods: Patients from the MS Center of the Hospital Italiano de Buenos Aires, Argentina were selected. To be included, patients must fulfilled RRMS criteria (McDonald 2005 or Poser), had no more than 3 years since the beginning of the disease (first demyelinating symptom) and no history of cognitive impairment. Once they were included, brain MRI was performed and juxtacortical lesion volume in T2 and proton density sequences were analyzed. Cognitive performance was evaluated by Paced Auditory Serial Adition Test (PASAT). The relationship between juxtacortical lesion volume and PASAT score was examined using regression analyses. Results: 28 patients were included. 18 (64%) were women, mean age 29.8 ± 3.6 years, mean time from disease onset 1.8 ± 0.7 years. 26 (92%) were on immunomodulatory treatments. Mean juxtacortical lesion volume was 278 ± 189 mm3. After adjusting for covariates, performance on PASAT was negatively correlated with juxtacortical lesion volume (r-0.73 p=0.001). Conclusions: We found a strong negative correlation between juxtacortical lesion volume and cognitive performance in early onset of RRMS. This is the first study of it9s kind in our population. Disclosure: Dr. Rojas has nothing to disclose. Dr. Patrucco has nothing to disclose. Dr. Tizio has nothing to disclose. Dr. Cristiano has nothing to disclose." @default.
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- W2334184609 date "2012-04-22" @default.
- W2334184609 modified "2023-09-27" @default.
- W2334184609 title "Juxtacortical Lesion Volume and Cognitive Performance in Early Onset of Relapsing Remitting Multiple Sclerosis (P03.077)" @default.
- W2334184609 doi "https://doi.org/10.1212/wnl.78.1_meetingabstracts.p03.077" @default.
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