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- W2335984595 abstract "Introduction. The expansion of synovial epithelium in Rheumatoid Arthritis (RA), and the subsequent pannus invasion of underlying cartilage and bone, needs an increase in the vascular supply to the synovium. Angiogenesis is recognised as a key event in the formation and maintenance of the pannus in RA. The pro-angiogenic cytokine, vascular endothelial growth factor (VEGF), has been demonstrated to have a central involvement in the angiogenic process in RA. Therefore we evaluated gene expression levels of a set of genes associated with angiogenesis in Synovial Fluid (SF) from RA patients compared with osteoarthritis patients. Patients and Methods: Knee SF samples were classified in two groups, Group I: RA with DAS 28 score > 5.1, high disease activity (n=10, 7F/3M, age: 56,3 ± 20,9, range: 17-84) and Group II: Osteoarthritis (OA, n=18, 13F/5M, age: 70,5 ± 6,6, range: 58-86). Levels of gene expression of three genes previously associated with angiogenesis, including proangiogenic factors: VEGF and Angiopoietin 1 (ANGPT-1) and anti-angiogenic factor, Thrombospondin I (TSP1) were evaluated using Quantitative Real Time PCR (QPCR). All amplifications were carried out in duplicate and threshold cycle (C t ) scores were averaged for calculations of relative expression values. The C t scores were normalized against C t scores by subtracting the corresponding β2Microglobuline (β2M) control, or ΔCt=C t,gene - C t,B2M . To test for differential gene expression between groups, a two sample t-test was performed to compare the ΔCt in the two groups. Results: Gene expression level is showed in table 1." @default.
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- W2335984595 date "2002-01-01" @default.
- W2335984595 modified "2023-09-26" @default.
- W2335984595 title "Angiogenesis in Rheumatoid Arthritis: VEGF expression in Synovial Fluid." @default.
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