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- W2340269425 abstract "Objective To study the influence of Klebsiella pneumoniae biofilm on the expressions of Toll like receptors mRNA and Cytokines and explore the mechanismof anti-bacterial biofilm in mouse peritoneal macrophage.Method Forty kunming mice were randomly divided into experiment group and control group.The mRNA expression level of TLRs was detected by rea-time polymerase chain reaction.Plasma Cytokines levels were measured by double antibody enzyme linked-immunosorbent assay.Result The TLR2 and TLR4 mRNA expressions of macrophage in experiment group were 0.23 and 0.24 fold compared to the control group,while there was no difference between the expressions of TLR5 and TLR9.After the stimulation,the levels of IL-1 and IL-2 in experiment group decreased significantly while that of IL-4 increased,compared to the control group(P0.01).Conclusion Bacterial biofilm can reduce the TLR2 and TLR4 expression levels and induce Th2 immune response.This may be one of the mechanisms of chronic infection caused by bacterial biofilm which can escape from host immune defense more easily.than bacterioplankton." @default.
- W2340269425 created "2016-06-24" @default.
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- W2340269425 date "2010-01-01" @default.
- W2340269425 modified "2023-09-28" @default.
- W2340269425 title "Influence of Klebsiella pneumoniae biofilm on immunological function in mouse macrophage." @default.
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