FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340330554> ?p ?o ?g. }

• W2340330554 endingPage "253" @default.
• W2340330554 startingPage "245" @default.
• W2340330554 abstract "The RNA polymerase of influenza virus consists of three subunits: PA, PB1 and PB2. It uses a unique `cap-snatching' mechanism for the transcription of viral mRNAs. The cap-binding domain of the PB2 subunit (PB2cap) in the viral polymerase binds the cap of a host pre-mRNA molecule, while the endonuclease of the PA subunit cleaves the RNA 10-13 nucleotides downstream from the cap. The capped RNA fragment is then used as the primer for viral mRNA transcription. The structure of PB2cap from influenza virus H1N1 A/California/07/2009 and of its complex with the cap analog m(7)GTP were solved at high resolution. Structural changes are observed in the cap-binding site of this new pandemic influenza virus strain, especially the hydrophobic interactions between the ligand and the target protein. m(7)GTP binds deeper in the pocket than some other virus strains, much deeper than the host cap-binding proteins. Analysis of the new H1N1 structures and comparisons with other structures provide new insights into the design of small-molecule inhibitors that will be effective against multiple strains of both type A and type B influenza viruses." @default.
• W2340330554 created "2016-06-24" @default.
• W2340330554 creator A5009755163 @default.
• W2340330554 creator A5018627514 @default.
• W2340330554 creator A5030212863 @default.
• W2340330554 creator A5048775238 @default.
• W2340330554 creator A5068870075 @default.
• W2340330554 creator A5086173720 @default.
• W2340330554 date "2016-01-22" @default.
• W2340330554 modified "2023-09-27" @default.
• W2340330554 title "The cap-binding site of influenza virus protein PB2 as a drug target" @default.
• W2340330554 cites W1979122114 @default.
• W2340330554 cites W1979228574 @default.
• W2340330554 cites W1983693962 @default.
• W2340330554 cites W1985415968 @default.
• W2340330554 cites W1986371311 @default.
• W2340330554 cites W1994713811 @default.
• W2340330554 cites W2023176508 @default.
• W2340330554 cites W2052912430 @default.
• W2340330554 cites W2074097848 @default.
• W2340330554 cites W2074561908 @default.
• W2340330554 cites W2108921801 @default.
• W2340330554 cites W2117918599 @default.
• W2340330554 cites W2132789646 @default.
• W2340330554 cites W2157725602 @default.
• W2340330554 cites W2002483831 @default.
• W2340330554 doi "https://doi.org/10.1107/s2059798316000085" @default.
• W2340330554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26894672" @default.
• W2340330554 hasPublicationYear "2016" @default.
• W2340330554 type Work @default.
• W2340330554 sameAs 2340330554 @default.
• W2340330554 citedByCount "18" @default.
• W2340330554 countsByYear W23403305542016 @default.
• W2340330554 countsByYear W23403305542017 @default.
• W2340330554 countsByYear W23403305542018 @default.
• W2340330554 countsByYear W23403305542019 @default.
• W2340330554 countsByYear W23403305542020 @default.
• W2340330554 countsByYear W23403305542021 @default.
• W2340330554 crossrefType "journal-article" @default.
• W2340330554 hasAuthorship W2340330554A5009755163 @default.
• W2340330554 hasAuthorship W2340330554A5018627514 @default.
• W2340330554 hasAuthorship W2340330554A5030212863 @default.
• W2340330554 hasAuthorship W2340330554A5048775238 @default.
• W2340330554 hasAuthorship W2340330554A5068870075 @default.
• W2340330554 hasAuthorship W2340330554A5086173720 @default.
• W2340330554 hasConcept C104292427 @default.
• W2340330554 hasConcept C104317684 @default.
• W2340330554 hasConcept C105580179 @default.
• W2340330554 hasConcept C107824862 @default.
• W2340330554 hasConcept C10852380 @default.
• W2340330554 hasConcept C118716 @default.
• W2340330554 hasConcept C138885662 @default.
• W2340330554 hasConcept C140704245 @default.
• W2340330554 hasConcept C153911025 @default.
• W2340330554 hasConcept C159047783 @default.
• W2340330554 hasConcept C179926584 @default.
• W2340330554 hasConcept C181199279 @default.
• W2340330554 hasConcept C185592680 @default.
• W2340330554 hasConcept C2522874641 @default.
• W2340330554 hasConcept C2776449523 @default.
• W2340330554 hasConcept C2777546802 @default.
• W2340330554 hasConcept C2780879997 @default.
• W2340330554 hasConcept C41258723 @default.
• W2340330554 hasConcept C41895202 @default.
• W2340330554 hasConcept C55493867 @default.
• W2340330554 hasConcept C58475186 @default.
• W2340330554 hasConcept C67705224 @default.
• W2340330554 hasConcept C82381507 @default.
• W2340330554 hasConcept C86803240 @default.
• W2340330554 hasConceptScore W2340330554C104292427 @default.
• W2340330554 hasConceptScore W2340330554C104317684 @default.
• W2340330554 hasConceptScore W2340330554C105580179 @default.
• W2340330554 hasConceptScore W2340330554C107824862 @default.
• W2340330554 hasConceptScore W2340330554C10852380 @default.
• W2340330554 hasConceptScore W2340330554C118716 @default.
• W2340330554 hasConceptScore W2340330554C138885662 @default.
• W2340330554 hasConceptScore W2340330554C140704245 @default.
• W2340330554 hasConceptScore W2340330554C153911025 @default.
• W2340330554 hasConceptScore W2340330554C159047783 @default.
• W2340330554 hasConceptScore W2340330554C179926584 @default.
• W2340330554 hasConceptScore W2340330554C181199279 @default.
• W2340330554 hasConceptScore W2340330554C185592680 @default.
• W2340330554 hasConceptScore W2340330554C2522874641 @default.
• W2340330554 hasConceptScore W2340330554C2776449523 @default.
• W2340330554 hasConceptScore W2340330554C2777546802 @default.
• W2340330554 hasConceptScore W2340330554C2780879997 @default.
• W2340330554 hasConceptScore W2340330554C41258723 @default.
• W2340330554 hasConceptScore W2340330554C41895202 @default.
• W2340330554 hasConceptScore W2340330554C55493867 @default.
• W2340330554 hasConceptScore W2340330554C58475186 @default.
• W2340330554 hasConceptScore W2340330554C67705224 @default.
• W2340330554 hasConceptScore W2340330554C82381507 @default.
• W2340330554 hasConceptScore W2340330554C86803240 @default.
• W2340330554 hasIssue "2" @default.
• W2340330554 hasLocation W23403305541 @default.
• W2340330554 hasLocation W23403305542 @default.
• W2340330554 hasOpenAccess W2340330554 @default.
• W2340330554 hasPrimaryLocation W23403305541 @default.

• next