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- W2343574706 abstract "Background When using area under the concentration–time curve–based strategies for dosing carboplatin, accurate estimation of glomerular filtration rate is required for determining dose. Commonly, the Cockcroft–Gault equation is used, which is dependent on measurement of serum creatinine ( SC r). Because analysis of SC r changed to an isotope dilution mass spectrometry ( IDMS ) standard, we sought to determine the impact of this assay change on carboplatin dosing and related toxicity. Methods This was a single‐center, retrospective chart review of adults treated with carboplatin between April 2008 and April 2010 divided into cohorts that initiated carboplatin before or after IDMS standardization. End points included grade 3 thrombocytopenia, decrease in platelet count, and hospitalization and were evaluated in cohorts based on concomitant chemotherapy. Results The chart review identified 158 patients, with 63 patients in the pre‐ IDMS group and 95 patients in the post‐ IDMS group. Average SC r (pre 1.01 mg/dl vs post 0.86 mg/dl, p<0.001) and average carboplatin dose (pre 580 mg vs post 703 mg, p<0.001) were significantly different between the groups. The frequency of grade 3 thrombocytopenia was not statistically significant across three partner chemotherapy cohorts before and after IDMS implementation. Conclusion IDMS standardization led to an overall decrease in SC r with subsequent increase in carboplatin doses. However, no increase in recorded adverse events was observed, suggesting that the clinical relevance in toxicity from higher doses was minimal." @default.
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- W2343574706 date "2016-06-01" @default.
- W2343574706 modified "2023-10-16" @default.
- W2343574706 title "Impact of Isotope Dilution Mass Spectrometry (IDMS) Standardization on Carboplatin Dose and Adverse Events" @default.
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- W2343574706 doi "https://doi.org/10.1002/phar.1759" @default.
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