Matches in SemOpenAlex for { <https://semopenalex.org/work/W2348561938> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2348561938 abstract "AIM To investigate the pharmacokinetic profile of carbamazepine (CBZ) in Chinese epilepsy patients. METHODS Steady state serum concentration data( n =703) were collected prospectively from 592 patients of 4 hospitals in Shanghai and Beijing during their routine clinical care. The values of the absorption rate, bioavailability and volume of distribution were fixed according to the literature. Only population clearance (CL) was calculated by NONMEM program, with a one compartment model of first order absorption and elimination. RESULTS Total body weight (TBW), dose and comedication of valproic sodium (VPA) and its dose greater than 20 mg·kg -1 ·d -1 , phenytoin (PHT), phenobarbital (PB) and the elder greater than 65 (ELDER) were all important determinants of CL. Sex and comedication of clonazepam or topiramate did not influence the CL of CBZ. The final model for clearance was: CL(CL/F)(L/h)=1 32·Dose(g·kg -1 ·d -1 ) 0 421 ·TBW(kg) 0.691 ·1 20 VPA ·1 43 PHT ·1 14 PB ·0 836 ELDER . CONCLUSION A population pharmacokinetic model is proposed to estimate the individual CL for Chinese patients receiving CBZ in term of patient's dose, TBW and comedications, in order to establish a prior dosage regimen." @default.
- W2348561938 created "2016-06-24" @default.
- W2348561938 creator A5000398995 @default.
- W2348561938 date "2003-01-01" @default.
- W2348561938 modified "2023-09-27" @default.
- W2348561938 title "The estimation of clearance of carbamazepine in chinese epileptic patients by NONMEM" @default.
- W2348561938 hasPublicationYear "2003" @default.
- W2348561938 type Work @default.
- W2348561938 sameAs 2348561938 @default.
- W2348561938 citedByCount "0" @default.
- W2348561938 crossrefType "journal-article" @default.
- W2348561938 hasAuthorship W2348561938A5000398995 @default.
- W2348561938 hasConcept C112705442 @default.
- W2348561938 hasConcept C118552586 @default.
- W2348561938 hasConcept C139254425 @default.
- W2348561938 hasConcept C181389837 @default.
- W2348561938 hasConcept C2775858608 @default.
- W2348561938 hasConcept C2776239304 @default.
- W2348561938 hasConcept C2777172819 @default.
- W2348561938 hasConcept C2777683783 @default.
- W2348561938 hasConcept C2778186239 @default.
- W2348561938 hasConcept C2778337148 @default.
- W2348561938 hasConcept C2778802184 @default.
- W2348561938 hasConcept C2779253243 @default.
- W2348561938 hasConcept C2779426884 @default.
- W2348561938 hasConcept C2908647359 @default.
- W2348561938 hasConcept C71924100 @default.
- W2348561938 hasConcept C98274493 @default.
- W2348561938 hasConcept C99454951 @default.
- W2348561938 hasConceptScore W2348561938C112705442 @default.
- W2348561938 hasConceptScore W2348561938C118552586 @default.
- W2348561938 hasConceptScore W2348561938C139254425 @default.
- W2348561938 hasConceptScore W2348561938C181389837 @default.
- W2348561938 hasConceptScore W2348561938C2775858608 @default.
- W2348561938 hasConceptScore W2348561938C2776239304 @default.
- W2348561938 hasConceptScore W2348561938C2777172819 @default.
- W2348561938 hasConceptScore W2348561938C2777683783 @default.
- W2348561938 hasConceptScore W2348561938C2778186239 @default.
- W2348561938 hasConceptScore W2348561938C2778337148 @default.
- W2348561938 hasConceptScore W2348561938C2778802184 @default.
- W2348561938 hasConceptScore W2348561938C2779253243 @default.
- W2348561938 hasConceptScore W2348561938C2779426884 @default.
- W2348561938 hasConceptScore W2348561938C2908647359 @default.
- W2348561938 hasConceptScore W2348561938C71924100 @default.
- W2348561938 hasConceptScore W2348561938C98274493 @default.
- W2348561938 hasConceptScore W2348561938C99454951 @default.
- W2348561938 hasLocation W23485619381 @default.
- W2348561938 hasOpenAccess W2348561938 @default.
- W2348561938 hasPrimaryLocation W23485619381 @default.
- W2348561938 hasRelatedWork W1978002828 @default.
- W2348561938 hasRelatedWork W1981294524 @default.
- W2348561938 hasRelatedWork W2006747187 @default.
- W2348561938 hasRelatedWork W2020977915 @default.
- W2348561938 hasRelatedWork W2024715299 @default.
- W2348561938 hasRelatedWork W2055825031 @default.
- W2348561938 hasRelatedWork W2083021417 @default.
- W2348561938 hasRelatedWork W2113632645 @default.
- W2348561938 hasRelatedWork W2123801201 @default.
- W2348561938 hasRelatedWork W2163596677 @default.
- W2348561938 hasRelatedWork W2183752182 @default.
- W2348561938 hasRelatedWork W2267930951 @default.
- W2348561938 hasRelatedWork W2365234186 @default.
- W2348561938 hasRelatedWork W2369747677 @default.
- W2348561938 hasRelatedWork W2383450094 @default.
- W2348561938 hasRelatedWork W2387176972 @default.
- W2348561938 hasRelatedWork W2394912585 @default.
- W2348561938 hasRelatedWork W2442767649 @default.
- W2348561938 hasRelatedWork W2793043893 @default.
- W2348561938 hasRelatedWork W2897748667 @default.
- W2348561938 isParatext "false" @default.
- W2348561938 isRetracted "false" @default.
- W2348561938 magId "2348561938" @default.
- W2348561938 workType "article" @default.