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- W2351650012 abstract "Objective To detect the expression and disposition of TGF beta 1 in the gastric carcinoma tissue and the corresponding normal mucosal tissue, and to analyze the relations between the expression, disposition and the clinicopathologic characteristics.Methods 39 cases of gastric cancer and normal tissues confirmed by histopathology were selected to detect and compare in the level of mRNA and protein by means of RT-PCR and frozen section immunohistochemistry staining technology. Results 30 cases (76.9%) were positive for TGF beta 1 mRNA expression and 23 cases were positive for TGF beta 1 staining. There are significance between stage Ⅰgroup and stage Ⅱ, Ⅲ, Ⅳ group as far as TGF beta 1 expression is concerned ,the same to T1 depth of invasion and T2、T3、T4 depth of invasion(P0.05). Frequently, strong TGF beta 1 staining occurred in gastric signet-ring cell carcinoma. Conclusion The TGF beta 1 plays an important role in the pathogenesis of gastric carcinoma. It appears to be a molecule marker in the early diagnose,management and prognostic about gastric carnoma." @default.
- W2351650012 created "2016-06-24" @default.
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- W2351650012 date "2009-01-01" @default.
- W2351650012 modified "2023-09-24" @default.
- W2351650012 title "Study of expression of Transforming growth factor beta 1 in gastric carcinoma tissue" @default.
- W2351650012 hasPublicationYear "2009" @default.
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