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- W2353936210 abstract "Objective To investigate the anti-inflammatory effect of sofalcone(SFN) in H. pylori-infected gastric epithelial cells in vitro. Methods Gastric epithelial cell line AGS was cultured in vitro, and then was incubated with SFN and H. pylori for different lengths of time. Expressions of IκBα and cyclooxygenase-2(COX-2) were detected by Western blot; the mRNA levels of COX-2 and MUC-2 were measured by real-time PCR; and production of reactive oxygen species(ROS) and IL-8 was detected by fluorescent probe and ELISA, respectively. Results After treatment with SFN, IκBα expression was significantly increased, nuclear factor kappa B activation was inhibited, and expressions of COX-2, ROS, and IL-8 were decreased. Meanwhile, SFN also increased the mRNA expression of MUC-2. Conclusions Sofalcone effectively inhibits activation of NF-κB and production of related inflammatory factors, while increases MUC-2 expression in H. pylori-infected AGS cells. It shows great potential as a candidate agent for the prevention of H. pylori-induced inflammation in gastric epithelial cells." @default.
- W2353936210 created "2016-06-24" @default.
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- W2353936210 date "2014-01-01" @default.
- W2353936210 modified "2023-09-23" @default.
- W2353936210 title "Anti-inflammatory effect of sofalcone in Helicobacter pylori-infected gastric epithelial cells in vitro" @default.
- W2353936210 hasPublicationYear "2014" @default.
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