Matches in SemOpenAlex for { <https://semopenalex.org/work/W2355137411> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2355137411 abstract "Objective To investigate the associations of single nucleotide polymorphisms(SNP) of human growth hormone receptor(GHR) with genetic susceptibility to idiopathic short stature(ISS) in Chinese Han populations. Methods Case-control method was employed,and 199 children with ISS(ISS group) and 469 adults with normal weight(control group) were enrolled.Genotyping and comparison were performed in 16 SNP sites of GHR gene,positive SNP sites(significant differences in specific genotypic frequency) were screened,and the associations of genotypes of positive SNP sites with risks of ISS and related clinical variables such as serum insulin-like growth factor 1(IGF-1)were analysed. Results Three positive SNP sites of rs6182(P=0.027),rs4410646(P=0.01) and rs10044169(P=0.024)were found in ISS group and control group.For rs6182(G/T),the risk of ISS of genotype TT and genotype GT decreased under T dominant mode(OR=0.624,95%CI:0.402-0.969,P=0.021).For rs4410646(A/C),the risk of ISS of genotype AA decreased under C dominant mode(OR=0.674,95%CI:0.475-0.958,P=0.016).Multivariate Logistics regression analysis of this site revealed that serum IGF-1 was related to genotype AA(OR=1.011,95%CI:1.002-1.020,P=0.018) and genotype CA(OR=1.010,95%CI:1.001-1.019,P=0.037) with genotype CC as reference,and serum IGF-1 was related to genotype CC(OR=0.989,95%CI:0.980-0.998,P=0.018) with genotype AA as reference.For rs10044169(A/C),the risk of ISS of genotype CC and genotype CA significantly decreased(OR=0.649,95%CI:0.424-0.993,P=0.027) under C dominant mode. Conclusion GHR plays a role in the growth promotion effect mediated by growth hormone,and 3 SNP sites of human GHR gene may be related to genetic susceptibility to ISS." @default.
- W2355137411 created "2016-06-24" @default.
- W2355137411 creator A5036436242 @default.
- W2355137411 date "2011-01-01" @default.
- W2355137411 modified "2023-09-23" @default.
- W2355137411 title "Associations of single nucleotide polymorphisms of growth hormone receptor with susceptibility to idiopathic short stature" @default.
- W2355137411 hasPublicationYear "2011" @default.
- W2355137411 type Work @default.
- W2355137411 sameAs 2355137411 @default.
- W2355137411 citedByCount "1" @default.
- W2355137411 countsByYear W23551374112013 @default.
- W2355137411 crossrefType "journal-article" @default.
- W2355137411 hasAuthorship W2355137411A5036436242 @default.
- W2355137411 hasConcept C104317684 @default.
- W2355137411 hasConcept C113675107 @default.
- W2355137411 hasConcept C126322002 @default.
- W2355137411 hasConcept C134018914 @default.
- W2355137411 hasConcept C135763542 @default.
- W2355137411 hasConcept C139275648 @default.
- W2355137411 hasConcept C153209595 @default.
- W2355137411 hasConcept C2778754045 @default.
- W2355137411 hasConcept C2984496839 @default.
- W2355137411 hasConcept C31467283 @default.
- W2355137411 hasConcept C54355233 @default.
- W2355137411 hasConcept C71315377 @default.
- W2355137411 hasConcept C71924100 @default.
- W2355137411 hasConcept C86803240 @default.
- W2355137411 hasConceptScore W2355137411C104317684 @default.
- W2355137411 hasConceptScore W2355137411C113675107 @default.
- W2355137411 hasConceptScore W2355137411C126322002 @default.
- W2355137411 hasConceptScore W2355137411C134018914 @default.
- W2355137411 hasConceptScore W2355137411C135763542 @default.
- W2355137411 hasConceptScore W2355137411C139275648 @default.
- W2355137411 hasConceptScore W2355137411C153209595 @default.
- W2355137411 hasConceptScore W2355137411C2778754045 @default.
- W2355137411 hasConceptScore W2355137411C2984496839 @default.
- W2355137411 hasConceptScore W2355137411C31467283 @default.
- W2355137411 hasConceptScore W2355137411C54355233 @default.
- W2355137411 hasConceptScore W2355137411C71315377 @default.
- W2355137411 hasConceptScore W2355137411C71924100 @default.
- W2355137411 hasConceptScore W2355137411C86803240 @default.
- W2355137411 hasLocation W23551374111 @default.
- W2355137411 hasOpenAccess W2355137411 @default.
- W2355137411 hasPrimaryLocation W23551374111 @default.
- W2355137411 hasRelatedWork W2083149485 @default.
- W2355137411 hasRelatedWork W2366663875 @default.
- W2355137411 hasRelatedWork W2376400064 @default.
- W2355137411 hasRelatedWork W2385810148 @default.
- W2355137411 hasRelatedWork W2388810824 @default.
- W2355137411 hasRelatedWork W2398680831 @default.
- W2355137411 hasRelatedWork W2412539166 @default.
- W2355137411 hasRelatedWork W2419550967 @default.
- W2355137411 hasRelatedWork W2547725854 @default.
- W2355137411 hasRelatedWork W2792546784 @default.
- W2355137411 hasRelatedWork W2810110056 @default.
- W2355137411 hasRelatedWork W2904635094 @default.
- W2355137411 hasRelatedWork W2982626594 @default.
- W2355137411 hasRelatedWork W2996084653 @default.
- W2355137411 hasRelatedWork W3013415625 @default.
- W2355137411 hasRelatedWork W3027276533 @default.
- W2355137411 hasRelatedWork W3028629015 @default.
- W2355137411 hasRelatedWork W3032241467 @default.
- W2355137411 hasRelatedWork W3111378357 @default.
- W2355137411 hasRelatedWork W761558260 @default.
- W2355137411 isParatext "false" @default.
- W2355137411 isRetracted "false" @default.
- W2355137411 magId "2355137411" @default.
- W2355137411 workType "article" @default.