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- W2356667818 abstract "High mobility group protein B1(HMGB1) is a DNA-binding nonhistone protein ubiquitously in the cell nucleus,which is concerned with gene transcription,DNA recombination and repair,and construction and stabilization of nucleosomes.HMGB1 is actively secreted by activated cells and is passively released from damaged or necrotic cells into the extracellular milieu.Extracellular HMGB1 binds to several membrane receptors including the receptor for advanced glycation end products(RAGE) and Toll-like receptors,resulting in intracellular signal transduction,and mediates inflammatory immune response,cell proliferation,cell differentiation and cell migration.Recent researches indicated that the expression and release of HMGB1 are markedly increased in digestive system cancers including hepatocellular carcinoma,colorectal carcinoma,gastric cancer and pancreatic cancer,and that HMGB1 plays an important role in tumorigenesis,development,invasion and metastasis.The researches for HMGB1-targeting therapies of cancers have arosen increasing attention.Some agents targeting HMGB1 have been used in cancer therapeutics,including HMGB1-neutralizing antibodies,ethyl pyruvate,sRAGE and siRNA." @default.
- W2356667818 created "2016-06-24" @default.
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- W2356667818 date "2013-01-01" @default.
- W2356667818 modified "2023-09-23" @default.
- W2356667818 title "High mobility group protein B1 and digestive system cancers" @default.
- W2356667818 hasPublicationYear "2013" @default.
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