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- W2357908275 abstract "OBJECTIVE:To explore the relationship between microsatellite alterations of FHIT gene and HPV infection and the development of cervical carcinoma.METHODS:Two sites of microsatellite polymorphism of FHIT gene were selected,and LOH and MI were detected with polymerase chain reaction(PCR)technique in 50 cases of cervical carcinoma and 40 cases of cervical intraepithelial neoplasia(CIN),and the infection state of HPV16 was also detected.RESULTS:At D3S1234,the LOH rate of cervical carcinomas and CINs were 46%(23/50)and 40%(16/40)separately.There was no significant difference between cervical carcinomas and CINs,P=0.361.The MI rate of cervical carcinomas and CINs were 18%(9/50)and 12.5%(5/40)separately.There was no significant difference between cervical carcinomas and CINs,P=0.339.At D3S4103,the LOH rate of cervical carcinomas and CINs were 40%(20/50)and 37.5%(15/40)separately.There was no significant difference between cervical carcinomas and CINs,P=0.491.The MI rate of cervical carcinomas and CINs were 14%(7/50)and 7.5%(3/40)separately.There was no significant difference between cervical carcinomas and CINs,P=0.265.The rates of LOH and MI for cervical carcinomas were higher than those for CIN.In 50 cervical carcinomas,the positive rates of LOH for HPV16 infenction were 79.5%(35/44),and MI were 31.8%(14/44);the negative rate of LOH was 33.3%(2/6),MI 16.7%(1/6),and there was a significant difference between HPV16(+)and HPV16(-)in respect to their positive rate of LOH,P=0.003,no significant difference of MI,P=0.645.In 40 CINs,the positive rate of LOH for HPV16 infenction was 82.4%(14/17),MI 35.3%(6/17);the negative rate of LOH was 52.2%(12/23),MI 17.4(4/23),and there was a significant difference between HPV16(+)and HPV16(-)in respect to their positive rate of LOH,P=0.048,no significant difference of MI,P=0.274.CONCLUSION:The FHIT gene change is a relatively late event in cervical carcinomas." @default.
- W2357908275 created "2016-06-24" @default.
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- W2357908275 date "2008-01-01" @default.
- W2357908275 modified "2023-09-24" @default.
- W2357908275 title "Study on relationship between microsatellite alterations of FHIT gene and HPV infection and cervical carcinoma" @default.
- W2357908275 hasPublicationYear "2008" @default.
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