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- W2359791112 abstract "Objective To investigate the myocardial protective effects of ginsenoside Re on rats with diabetes mellitus and the mechanism. Methods Forty healthy male Wistar rats were given streptozotocin( STZ) 35 mg / kg by intraperitoneal injection to make diabetic models. After 72 hours,34 models were successful made. Then they were randomly divided into the diabetic model group( DM group,n = 12),ginsenoside Re group( Re group,n = 11) and pioglitazone group( P group,n = 11) and were given corresponding amount of pure water,ginsenoside Re 25 mg /( kg·d) and pioglitazone 10 mg /( kg·d) by intragastric administration for four weeks in a row. Another 10 healthy male Wistar rates were given standard feed as the control group( control group). All rats were killed after 4 weeks. Glucose and lipids were tested. The superoxide dismutase( SOD) activities and contents of MDA in serum and myocardial tissues were detected respectively. Results The levels of fasting blood glucose and serum total cholesterol in the Re and P groups were higher than those of the control group,lower than those of the DM group( all P 0. 01),but no significant difference was found between the Re and P groups. Compared with the DM group,Re and P groups could increase the activity of SOD( P 0. 01) and decrease the content of MDA in serum and myocardial tissues( P 0. 05) and there was no significant difference between Re and P groups. Compared with the DM group,the myocardial injury was decreased,and myocardial cells arranged orderly in the Re and P groups. Conclusions Ginsenoside Re has myocardial protective effects on rats with diabetes mellitus. One of the mechanisms is the anti-lipid peroxidation." @default.
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- W2359791112 date "2013-01-01" @default.
- W2359791112 modified "2023-09-24" @default.
- W2359791112 title "Myocardial protective effects of ginsenoside Re on rats with diabetes mellitus" @default.
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