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- W2362700528 abstract "Objective:To observe the effect of Zhisheng Capsule on the rat model of esophageal cancer,inducing apoptosis and the impact on Fas,FasL protein expression.Method: Healthy Wistar rats were treated with MANA 5 mg·kg-1 for 18 weeks except normal group.After the last injection,the rats were randomly divided into the following groups:esophageal model group,Zhisheng Capsule high(0.75 g·kg-1),middle(0.5 g·kg-1),low(0.25 g·kg-1)dose groups,tegafur group(20 mg·kg-1).TUNEL assay was used to examine the effect of Zhisheng Capsule on apoptosis of esophageal cancer cells.Immunohisto-chemistry(IHC) technique was used to measure the expression of Fas and FasL protein in cells.Result: Zhisheng Capsule of three doses could promote apoptosis of esophageal cancer cells according to the result of TUNEL assay.Comparison with model group was significant(P0.05).High dose group was significantly better than chemotherapy group and low dose group(P0.05).There showed some dose-effect relationship.Measured with IHC,the expression of Fas protein in the cells dealt with Zhisheng Capsule was increased,whereas the expression of FasL protein was decreased.Conclusion: Zhisheng Capsule could promote apoptosis of esophageal cancer cells.The molecular mechanism of Zhisheng Capsule may be related with up-regulating of Fas and down-regulating the expression of FasL.In addition,the effects of Zhisheng Capsule to promote apoptosis of esophageal cancer cells and Fas,FasL showed some dose-effect relationship.The effect of the capsule was better than tegafur." @default.
- W2362700528 created "2016-06-24" @default.
- W2362700528 creator A5046119891 @default.
- W2362700528 date "2011-01-01" @default.
- W2362700528 modified "2023-09-24" @default.
- W2362700528 title "Effect of Zhisheng Capsule on Cell Apoptosis and Fas,FasL Protein Expression in Rats Model of Esophageal Cancer" @default.
- W2362700528 hasPublicationYear "2011" @default.
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