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- W2364632979 abstract "In the present study, we found that rHuIFN γ can enhance the localization of 131 I radiolabelled mAb Sc3A in human colon carcinoma xenografts of athymic mice as well as the effect of radioimmunotherapy. The tumor inhibitory rates of 131 I Sc3A F(ab′) 2 plus rHuIFN γ and 131 I Sc3A plus rHuIFN γ were 91.9% and 84.4%, respectively. While those of PBS plus 131 I Sc3A F(ab′) 2 and PBS plus 131 I Sc3A groups were 69.6% and 60.5%, respectively. In addition, the xenograft tumors in the specific mAb groups began to degenerate on day 5 after first injection of 131 I labelled mAb plus IFN γ. The tumor volume of the animals receiving 131 I Sc3A plus rHuIFN γ accounted for 19.4% of that of the animals receiving rHuIFN γ alone. While the tumor volumes of the animals receiving 131 I Sc3A F(ab′) 2 or 131 I Sc3A plus PBS accounted for 39.5% and 30.4% of that of the animals receiving PBS alone, respectively. These results indicated that rHuIFN γ could augment the curative effect of 131 I labelled specific mAbs in tumor targeting therapy." @default.
- W2364632979 created "2016-06-24" @default.
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- W2364632979 date "1998-01-01" @default.
- W2364632979 modified "2023-09-25" @default.
- W2364632979 title "Enhanced targeting of radioimmunotherapy for human colorectal carcinoma implanted in athymic mice by rHuIFN γ" @default.
- W2364632979 hasPublicationYear "1998" @default.
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